及时诊断和治疗具有非典型三联临床症状的日本斑疹热：病例报告。

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES Infection and Drug Resistance Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI:10.2147/IDR.S483309

Haoyi Wang, Zhen Ni, Yinghao Chang

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引用次数: 0

摘要

日本斑疹热（JSF）是一种被忽视的潜在致命传染病。日本斑疹热诊断和治疗的延误是导致预后不良的重要原因。我们报告了一例 75 岁农民的日本斑疹热病例，她在中国四川秋季田间劳作后出现了不典型的三联临床症状：高烧、瘀点状皮疹和明显的无鳞屑。由于没有得到适当的诊断和治疗，她出现了脓毒性休克和急性呼吸窘迫综合征。通过对血液进行元基因组下一代测序（mNGS），确定了日本立克次体，从而确诊为日本立克次体综合症。使用强力霉素治疗一周后，患者的临床症状缓解，没有任何不适症状。

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Prompt Diagnosis and Treatment of Japanese Spotted Fever with an Atypical Triad of Clinical Symptoms: A Case Report.

Japanese spotted fever (JSF) is a neglected and potentially fatal infectious disease. Delays in diagnosis and treatment of JSF are important causes of poor prognosis. We report a case of JSF in a 75-year-old farmer who, following autumn field work in Sichuan, China, presented with an atypical triad of clinical symptoms: high fever, petechial rash, and notably no eschar. Without appropriate diagnosis and treatment, she developed septic shock and acute respiratory distress syndrome. The diagnosis of JSF was confirmed by the identification of Rickettsia japonica by metagenomic next-generation sequencing (mNGS) of the blood. After one week of treatment with doxycycline, the patient's clinical symptoms subsided without any complaints of discomfort.

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.