羟氯喹诱发的急性全身泛发性脓疱病伴有 HLA-分型。

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics Pub Date : 2024-11-18 DOI:10.1080/14622416.2024.2430167

Qiaoli Zheng, Na Jin, Hao Cheng

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引用次数: 0

摘要

急性全身泛发性脓疱病（AGEP）是一种罕见的药物反应，其特征是在红斑基础上出现大量脓疱。在某些情况下，羟氯喹（HCQ）可导致 AGEP。根据药物基因组学研究，HLA基因与AGEP之间存在关联。在本病例报告中，我们介绍了一名 36 岁女性患者的病例，该患者因 HLA 类型而患上了 HCQ 引起的 AGEP。根据我们的研究结果，该患者的 HLA-B 基因为 58:01，HLA-C 基因为 08:01，HLA-A 基因为 02:06。这一结果从药物经济学的角度说明了在开药前进行 HLA 基因分型的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hydroxychloroquine-induced acute generalized exanthematous pustulosis with HLA-typing.

Acute generalized exanthematous pustulosis (AGEP) is a rare drug reaction characterized by numerous pustules on an erythematous base. In some cases, hydroxychloroquine (HCQ) can cause AGEP. There is an association between HLA genes and AGEP according to pharmacogenomic studies. In this case report, we present the case of a 36-year-old female who developed HCQ-induced AGEP with HLA-typing. According to our findings, the patient had HLA-B 58:01, HLA-C 08:01, and HLA-A 02:06. A pharmacoeconomic perspective of HLA genotyping before drug prescription is shown in this result.

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.