含黄素单氧化酶介导的新陈代谢的实践方面

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL Chemical Research in Toxicology Pub Date : 2024-11-01 DOI:10.1021/acs.chemrestox.4c0031610.1021/acs.chemrestox.4c00316

John R. Cashman*,

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引用次数: 0

摘要

从药物代谢的角度来看，肝脏含黄素单加氧酶 3（FMO3）可以说是人类最重要的 FMO。最近，成人肝脏 FMO3 与多种疾病有关，包括心脏代谢疾病、衰老、肥胖和小动物动脉粥样硬化。尽管相对于细胞色素 P-450 (CYP)，FMO3 在药物和化学品代谢中具有重要作用，但有关药物和化学品代谢的研究却较少。这可能与人类肝脏 FMO3 的特性有关。例如，FMO3 具有热敏性，而且研究人类肝脏 FMO3 的方法往往不尽人意。在此，我将介绍研究人肝 FMO3 和其他 FMO 的一些实用方法。

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Practical Aspects of Flavin-Containing Monooxygenase-Mediated Metabolism

Hepatic flavin-containing monooxygenase 3 (FMO3) is arguably the most important FMO in humans from the standpoint of drug metabolism. Recently, adult hepatic FMO3 has been linked to several conditions including cardiometabolic diseases, aging, obesity, and atherosclerosis in small animals. Despite the importance of FMO3 in drug and chemical metabolism, relative to cytochrome P-450 (CYP), fewer studies have been published describing drug and chemical metabolism. This may be due to the properties of human hepatic FMO3. For example, FMO3 is thermally labile, and often methods reported in the study of human hepatic FMO3 are not optimal. Herein, I describe some practical aspects for studying human hepatic FMO3 and other FMOs.

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.