Shuang Xiao, Chunyan Wang, Teng You, Ping Huang, Qiuxia Deng, Ping Jiang*, Peng Chen* and Daiping He*,
{"title":"部分氧化可提高 Ru 纳米粒子的氧化酶模拟活性，用于褪黑素比色检测","authors":"Shuang Xiao, Chunyan Wang, Teng You, Ping Huang, Qiuxia Deng, Ping Jiang*, Peng Chen* and Daiping He*, ","doi":"10.1021/acs.cgd.4c0131910.1021/acs.cgd.4c01319","DOIUrl":null,"url":null,"abstract":"<p >It is highly desirable but still remains challenging to tune nanozymes with superior catalytic activity via simple operation. Herein, the oxidase-like activity of Ru nanoparticles supported on porous carbon (Ru/PC) was significantly modulated via a facile partial oxidation process. Due to the small size, uniform dispersion, high electron density on the surface, as well as abundant interfacial heterostructure between Ru and RuO<sub>2</sub>, the partially oxidized Ru/PC (P–Ru/PC) showed excellent oxidase-mimicking activity in triggering 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation, with a low K<sub>m</sub> of 0.138 mM and a high <i>V</i><sub>max</sub> of 2.82 × 10<sup>–7</sup> M·s<sup>–1</sup>. Theoretical calculations reveal that both the absorption and subsequent activation of molecular oxygen are more favorable on the interfacial heterostructure of P–Ru/PC than on the Ru/PC surface. Moreover, the oxidase-like activity of P–Ru/PC was found to be suppressed by melatonin, along with a fading color of oxidized TMB (TMB<sub>ox</sub>). As a result, a novel colorimetric system consisting of P–Ru/PC and TMB was established for melatonin detection for the first time, which shows a wide linear range of 10–220 μM and a low detection limit of 0.023 μM. This work not only provides a simple but smart strategy of interface engineering to tune the oxidase-like activity of Ru/PC, but also expands the application of Ru oxidase mimics in pharmaceutical analysis.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"24 22","pages":"9838–9847 9838–9847"},"PeriodicalIF":3.2000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Partial Oxidation Boosts Ru Nanoparticles with Excellent Oxidase-Mimicking Activity for Melatonin Colorimetric Detection\",\"authors\":\"Shuang Xiao, Chunyan Wang, Teng You, Ping Huang, Qiuxia Deng, Ping Jiang*, Peng Chen* and Daiping He*, \",\"doi\":\"10.1021/acs.cgd.4c0131910.1021/acs.cgd.4c01319\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >It is highly desirable but still remains challenging to tune nanozymes with superior catalytic activity via simple operation. Herein, the oxidase-like activity of Ru nanoparticles supported on porous carbon (Ru/PC) was significantly modulated via a facile partial oxidation process. Due to the small size, uniform dispersion, high electron density on the surface, as well as abundant interfacial heterostructure between Ru and RuO<sub>2</sub>, the partially oxidized Ru/PC (P–Ru/PC) showed excellent oxidase-mimicking activity in triggering 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation, with a low K<sub>m</sub> of 0.138 mM and a high <i>V</i><sub>max</sub> of 2.82 × 10<sup>–7</sup> M·s<sup>–1</sup>. Theoretical calculations reveal that both the absorption and subsequent activation of molecular oxygen are more favorable on the interfacial heterostructure of P–Ru/PC than on the Ru/PC surface. Moreover, the oxidase-like activity of P–Ru/PC was found to be suppressed by melatonin, along with a fading color of oxidized TMB (TMB<sub>ox</sub>). As a result, a novel colorimetric system consisting of P–Ru/PC and TMB was established for melatonin detection for the first time, which shows a wide linear range of 10–220 μM and a low detection limit of 0.023 μM. This work not only provides a simple but smart strategy of interface engineering to tune the oxidase-like activity of Ru/PC, but also expands the application of Ru oxidase mimics in pharmaceutical analysis.</p>\",\"PeriodicalId\":34,\"journal\":{\"name\":\"Crystal Growth & Design\",\"volume\":\"24 22\",\"pages\":\"9838–9847 9838–9847\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Crystal Growth & Design\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.cgd.4c01319\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crystal Growth & Design","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.cgd.4c01319","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Partial Oxidation Boosts Ru Nanoparticles with Excellent Oxidase-Mimicking Activity for Melatonin Colorimetric Detection
It is highly desirable but still remains challenging to tune nanozymes with superior catalytic activity via simple operation. Herein, the oxidase-like activity of Ru nanoparticles supported on porous carbon (Ru/PC) was significantly modulated via a facile partial oxidation process. Due to the small size, uniform dispersion, high electron density on the surface, as well as abundant interfacial heterostructure between Ru and RuO2, the partially oxidized Ru/PC (P–Ru/PC) showed excellent oxidase-mimicking activity in triggering 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation, with a low Km of 0.138 mM and a high Vmax of 2.82 × 10–7 M·s–1. Theoretical calculations reveal that both the absorption and subsequent activation of molecular oxygen are more favorable on the interfacial heterostructure of P–Ru/PC than on the Ru/PC surface. Moreover, the oxidase-like activity of P–Ru/PC was found to be suppressed by melatonin, along with a fading color of oxidized TMB (TMBox). As a result, a novel colorimetric system consisting of P–Ru/PC and TMB was established for melatonin detection for the first time, which shows a wide linear range of 10–220 μM and a low detection limit of 0.023 μM. This work not only provides a simple but smart strategy of interface engineering to tune the oxidase-like activity of Ru/PC, but also expands the application of Ru oxidase mimics in pharmaceutical analysis.
期刊介绍：
The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials.
Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.
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