Experimental Data and Thermodynamic Modeling of Solid–Liquid and Liquid–Vapor Equilibria in the CO2 + Ethanol + Acetaminophen System

In this study, experimental carry out of liquid–vapor and solid–liquid phase transitions were conducted for the ternary system {CO₂ (1) + ethanol (2) + acetaminophen (3)} at different concentrations of paracetamol in ethanol for temperatures from 313 to 333 K and pressures up to 12 MPa. Experimental high pressure phase transition data were obtained using the static method in a variable volume view cell. Experimental data were compared with the literature for systems containing acetaminophen in a saturated solution. The presence of paracetamol in the binary system {CO₂ (1) + ethanol (2)} significantly alters the behavior of the phase under the conditions of temperature and concentration studied. It was observed that in the ternary system {CO₂ (1) + ethanol (2) + acetaminophen (3)} with a saturated solution at the lowest temperature, 313 K, CO₂ acts as a cosolvent for mole fractions lower than 0.6. Thermodynamic simulations employing the Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT) Equations of State (EoS) aligned the experimental results adequately. The observed minimal deviations in pressure and temperature validate the efficacy of the thermodynamic models applied in this study.