{"title":"铱催化的三级外消旋烯丙醇与吲哚的不对称烯丙基取代反应","authors":"Takahiro Sawano , Manami Kobayashi , Momoko Ishikawa , Eri Ishikawa , Ryo Takeuchi","doi":"10.1039/d4qo01671h","DOIUrl":null,"url":null,"abstract":"<div><div>We report an allenylic substitution of racemic tertiary allenylic alcohols with indoles by a cooperative catalyst consisting of iridium/(P,olefin)-ligand catalyst and Lewis acid to give allenylated indoles bearing a quaternary carbon center with good enantioselectivities. 7-Azaindoles also reacted with allenylic alcohols to form the corresponding allenylated products with high enantioselectivities.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 4","pages":"Pages 1080-1085"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Iridium-catalyzed asymmetric allenylic substitution of tertiary racemic allenylic alcohols with indoles†\",\"authors\":\"Takahiro Sawano , Manami Kobayashi , Momoko Ishikawa , Eri Ishikawa , Ryo Takeuchi\",\"doi\":\"10.1039/d4qo01671h\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>We report an allenylic substitution of racemic tertiary allenylic alcohols with indoles by a cooperative catalyst consisting of iridium/(P,olefin)-ligand catalyst and Lewis acid to give allenylated indoles bearing a quaternary carbon center with good enantioselectivities. 7-Azaindoles also reacted with allenylic alcohols to form the corresponding allenylated products with high enantioselectivities.</div></div>\",\"PeriodicalId\":94379,\"journal\":{\"name\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"volume\":\"12 4\",\"pages\":\"Pages 1080-1085\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2052412924008507\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412924008507","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/20 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Iridium-catalyzed asymmetric allenylic substitution of tertiary racemic allenylic alcohols with indoles†
We report an allenylic substitution of racemic tertiary allenylic alcohols with indoles by a cooperative catalyst consisting of iridium/(P,olefin)-ligand catalyst and Lewis acid to give allenylated indoles bearing a quaternary carbon center with good enantioselectivities. 7-Azaindoles also reacted with allenylic alcohols to form the corresponding allenylated products with high enantioselectivities.
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