Wei Liu, Dan Zhao, Dongxue Yin, Kai Duan, Zhihao Wang
{"title":"作为一种重要天然抗癌剂的鬼臼毒素的植物来源、含量概况和生物活性。","authors":"Wei Liu, Dan Zhao, Dongxue Yin, Kai Duan, Zhihao Wang","doi":"10.1002/cbdv.202402375","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Pharmacological studies have shown that podophyllotoxin (PTOX) has anti-tumor, antiviral, and anti-inflammatory effects. More and more derivatives of PTOX, such as VM-26, NK-611 and GL-331, have gradually been synthesized and are widely used in clinical practice. <i>Sinopodophyllum hexandrum</i> rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on <i>S. hexandrum</i> mainly focuses on artificial cultivation, chemical composition, pharmaceutical value, and the biosynthesis pathway of PTOX. However, the researches are relatively scattered, and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation of the plant origin source, content profile, and biological activities to provide an integrated reference for in-depth research and clinical application of PTOX in the fields of chemistry and pharmacy, which can promote the innovative use of <i>S. hexandrum</i> resources and research and development of new anticancer drugs.</p>\n </div>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"22 4","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent\",\"authors\":\"Wei Liu, Dan Zhao, Dongxue Yin, Kai Duan, Zhihao Wang\",\"doi\":\"10.1002/cbdv.202402375\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Pharmacological studies have shown that podophyllotoxin (PTOX) has anti-tumor, antiviral, and anti-inflammatory effects. More and more derivatives of PTOX, such as VM-26, NK-611 and GL-331, have gradually been synthesized and are widely used in clinical practice. <i>Sinopodophyllum hexandrum</i> rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on <i>S. hexandrum</i> mainly focuses on artificial cultivation, chemical composition, pharmaceutical value, and the biosynthesis pathway of PTOX. However, the researches are relatively scattered, and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation of the plant origin source, content profile, and biological activities to provide an integrated reference for in-depth research and clinical application of PTOX in the fields of chemistry and pharmacy, which can promote the innovative use of <i>S. hexandrum</i> resources and research and development of new anticancer drugs.</p>\\n </div>\",\"PeriodicalId\":9878,\"journal\":{\"name\":\"Chemistry & Biodiversity\",\"volume\":\"22 4\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry & Biodiversity\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202402375\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202402375","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent
Pharmacological studies have shown that podophyllotoxin (PTOX) has anti-tumor, antiviral, and anti-inflammatory effects. More and more derivatives of PTOX, such as VM-26, NK-611 and GL-331, have gradually been synthesized and are widely used in clinical practice. Sinopodophyllum hexandrum rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on S. hexandrum mainly focuses on artificial cultivation, chemical composition, pharmaceutical value, and the biosynthesis pathway of PTOX. However, the researches are relatively scattered, and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation of the plant origin source, content profile, and biological activities to provide an integrated reference for in-depth research and clinical application of PTOX in the fields of chemistry and pharmacy, which can promote the innovative use of S. hexandrum resources and research and development of new anticancer drugs.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
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