尸检毒理学对合成卡西酮的发现。

IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Forensic science international Pub Date : 2024-11-15 DOI:10.1016/j.forsciint.2024.112297
Pirkko Kriikku , Ilkka Ojanperä
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引用次数: 0

摘要

合成卡西酮(SC)是一组新的精神活性物质,具有类似苯丙胺的效果,但一般药效更高。本研究旨在评估芬兰尸检(PM)中SCs的发生率和重要性,重点关注三种最普遍的物质:α-PVP、α-PHP和α-PiHP。对2018-2023年期间所有SCs阳性的PM病例进行了调查,调查内容包括死因和死亡方式、PM血液和尿液浓度以及同时使用其他滥用药物的情况。在118例死亡病例中有136例发现α-PVP、α-PHP或α-PiHP,其中死亡年龄中位数为35岁,82%为男性。在 69-92% 的病例中发现了阿片类药物、兴奋剂或镇静剂,在 39-47% 的病例中发现了大麻。在两个病例(1.7%)中,仅发现了 SCs。在已查明的 34 例致命中毒事件(29%)中,死因至少与三种 SCs 中的一种有关。在这些中毒病例中,α-PVP、α-PHP 和 α-PiHP 的股静脉血浓度中位数(范围)分别为 0.18(0.03-2.6)毫克/升、0.16(0.02-0.58)毫克/升和 0.14(0.03-2.1)毫克/升。在所有药物滥用病例中发现α-PVP、α-PHP和α-PiHP的比例分别为4.0%和2.7%,而苯丙胺/甲基苯丙胺的比例分别为44%和21%。尽管SC在PM病例中的流行率较低,但其滥用责任和药物使用模式似乎与苯丙胺相似。
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Findings of synthetic cathinones in post-mortem toxicology
Synthetic cathinones (SCs) are a group of new psychoactive substances with amphetamine-like effects but generally higher potency. The aim of this study was to assess the incidence and significance of SCs in post-mortem (PM) investigations in Finland, focusing on the three most prevalent substances: α-PVP, α-PHP, and α-PiHP. All PM cases positive for SCs during 2018–2023 were investigated with respect to cause and manner of death, PM blood and urine concentrations, and concomitant use of other drugs of abuse. There were 136 findings of α-PVP, α-PHP, or α-PiHP in 118 death cases, in which the median age at death was 35 years and 82 % were males. Concomitant opioids, stimulants, or sedatives were found in 69–92 % of cases, and cannabis in 39–47 %. In two cases (1.7 %), SCs were the only findings of abused drugs. Thirty-four fatal poisonings (29 %) were identified in which at least one of the three SCs was implicated in the cause of death. The median (range) femoral blood concentrations of α-PVP, α-PHP, and α-PiHP in these poisoning cases were 0.18 (0.03–2.6) mg/L, 0.16 (0.02–0.58) mg/L, and 0.14 (0.03–2.1) mg/L, respectively. α-PVP, α-PHP and α-PiHP were found in 4.0 % of all drug abuse cases and in 2.7 % of all fatal poisonings related to drug abuse, while for amphetamine/methamphetamine, these figures were 44 % and 21 %, respectively. Despite their lower prevalence in PM cases, SCs appear to have similar abuse liability and similar drug use patterns to amphetamine.
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来源期刊
Forensic science international
Forensic science international 医学-医学:法
CiteScore
5.00
自引率
9.10%
发文量
285
审稿时长
49 days
期刊介绍: Forensic Science International is the flagship journal in the prestigious Forensic Science International family, publishing the most innovative, cutting-edge, and influential contributions across the forensic sciences. Fields include: forensic pathology and histochemistry, chemistry, biochemistry and toxicology, biology, serology, odontology, psychiatry, anthropology, digital forensics, the physical sciences, firearms, and document examination, as well as investigations of value to public health in its broadest sense, and the important marginal area where science and medicine interact with the law. The journal publishes: Case Reports Commentaries Letters to the Editor Original Research Papers (Regular Papers) Rapid Communications Review Articles Technical Notes.
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