血清鸢尾素水平与急性缺血性脑卒中发病率成反比:中国南方地区早期诊断的意义》。

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S483793
Fengshan Ouyang, Sheng Chen, Shuhuan Li, Lanyuan Liu, Senhong Guan, Zhaohan Yan, Shumin Wu, Yunying Zeng, Jiemei Liu, Jiankai Zhong
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引用次数: 0

摘要

研究目的本研究旨在探讨血清鸢尾素水平与急性缺血性脑卒中(AIS)及其后偏瘫发生的相关性和预后价值:本研究招募了南方医科大学顺德医院神经内科和康复医学科的参与者。采用 Fugl-Meyer 评估法评估功能障碍。采用酶联免疫吸附法测定血清鸢尾素水平。采用多变量逻辑回归法探讨与血清鸢尾素水平和 AIS 相关的因素:结果:AIS 组的血清鸢尾素水平明显低于对照组。结果:AIS 组血清鸢尾素水平明显低于对照组,但在 AIS 组群中,血清鸢尾素与中风严重程度无明显关联。多变量逻辑回归分析表明,血清鸢尾素水平与 AIS 风险呈反相关,表明鸢尾素是 AIS 的保护因素。血清鸢尾素水平的升高(调整后的几率比(OR)为 0.938,95% 置信区间 [CI]:0.899-0.977)可降低 AIS 风险:每 100 pg/mL 的增量为 0.899-0.977)与 AIS 风险的降低有关。接收器操作特征曲线分析证实了血清鸢尾素对 AIS 的诊断价值,曲线下面积为 0.591(95% CI:0.522-0.659,P = 0.012):结论:血清鸢尾素水平在 AIS 中明显较低,被认为是一个保护因素,这表明血清鸢尾素可能对 AIS 有诊断价值。
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Serum Irisin Levels are Inversely Correlated with Acute Ischaemic Stroke Incidence: Implications for Early Diagnosis in Southern China.

Objective: This study aimed to examine the correlation and prognostic value of serum irisin levels in acute ischaemic stroke (AIS) and the subsequent development of hemiplegia.

Methods: This study recruited participants from the Department of Neurology and Rehabilitation Medicine at Shunde Hospital, Southern Medical University. The Fugl-Meyer Assessment was used to assess functional impairment. Serum irisin levels were measured using the enzyme-linked immunosorbent assay method. Multivariate logistic regression was employed to explore the factors related to serum irisin levels and AIS.

Results: Serum irisin levels in the AIS group were significantly lower than those in the control group. However, no significant association was observed between serum irisin and stroke severity within the AIS cohort. Multivariate logistic regression analysis revealed an inverse correlation between serum irisin levels and AIS risk, indicating that it serves as a protective factor against AIS. The increase in serum irisin levels (adjusted odds ratio (OR) 0.938, 95% confidence interval [CI]: 0.899-0.977 per 100 pg/mL increment) was associated with a decreased risk of AIS. Analysis of the receiver operating characteristic curve confirmed the diagnostic value of serum irisin for AIS, with the area under the curve being 0.591 (95% CI: 0.522-0.659, p = 0.012).

Conclusion: Serum irisin levels were significantly lower in AIS and were identified as a protective factor, suggesting that serum irisin may have diagnostic value for AIS.

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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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