新风胶囊可降低类风湿关节炎患者的再入院风险:一项约 10000 人的队列研究。

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S491218
Fanfan Wang, Jian Liu, Yanyan Fang, Yue Sun, Mingyu He
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引用次数: 0

摘要

研究目的本研究旨在探讨新风胶囊(XFC)治疗与类风湿关节炎(RA)患者再入院风险之间的潜在关联:通过回顾性方法,收集了2013年至2021年间安徽中医药大学第一附属医院所有确诊为RA的住院患者的数据。为减少选择偏倚和混杂因素,根据患者的治疗状态,采用倾向得分匹配法,以1:2的比例将患者分为XFC组和非XFC(非XFC)组。对年龄、性别和基线药物等变量进行了调整。随后,采用 Cox 比例危险模型计算 RA 患者再入院的危险比(HR),并利用 Kaplan-Meier 曲线描述再入院的发生率:本研究共纳入了 9987 名 RA 患者。经过严格的纳入/排除标准和倾向得分匹配,XFC 组有 2036 名患者,而非 XFC 组有 4072 名患者。Cox 比例危险模型分析显示,XFC 是一种保护因素,能显著降低 RA 患者的再入院风险。对 Kaplan-Meier 曲线的进一步研究表明,使用 XFC 不仅能有效降低再入院的频率,而且随着使用时间的延长(超过 12 个月),在降低再入院风险方面的效果更加明显。此外,关联规则分析强调了XFC与避免再入院之间的紧密联系,以及XFC的使用与C3、C4、CRP、ESR等多项实验室指标的显著改善之间的紧密相关性:本研究强调了使用 XFC 与降低 RA 患者再入院率之间的长期稳健联系。作为降低这些患者再入院风险的保护因素,XFC 的临床价值值得进一步推广和研究。
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The Treatment with Xinfeng Capsule Can Reduce the Risk of Readmission for Patients with Rheumatoid arthritis:A Cohort Study of Approximately 10000 Individuals.

Objective: The present study aimed to investigate the potential association between the treatment with Xinfeng Capsule (XFC) and the risk of readmission among patients with rheumatoid arthritis (RA).

Methods: Through a retrospective approach, data were collected from all hospitalized patients diagnosed with RA at the First Affiliated Hospital of Anhui University of Chinese Medicine between 2013 and 2021. To mitigate selection bias and confounding factors, patients were stratified into an XFC group and a Non-XFC (Non-XFC) group based on their treatment status using propensity score matching with a 1:2 ratio. Variables such as age, gender, and baseline medications were adjusted. Subsequently, the Cox proportional hazards model was employed to calculate the hazard ratio (HR) for readmission among RA patients, while Kaplan-Meier curves were utilized to depict the incidence of readmission.

Results: A total of 9987 RA patients were included in this study. Following rigorous inclusion/exclusion criteria and propensity score matching, the XFC group comprised 2036 patients, while the Non-XFC group contained 4072 patients. The Cox proportional hazards model analysis revealed that XFC acted as a protective factor, significantly reducing the risk of readmission among RA patients. Further examination of Kaplan-Meier curves demonstrated that XFC use not only effectively lowered the frequency of readmissions but also exhibited a more pronounced effect in diminishing the risk of readmission with extended usage durations (beyond 12 months). Additionally, association rule analysis underscored the strong link between XFC and freedom from readmission, as well as the robust correlation between XFC usage and significant improvements in multiple laboratory indicators, including C3, C4, CRP, ESR, and others.

Conclusion: This study underscores a robust and long-term association between XFC usage and lower readmission rates among RA patients. As a protective factor against readmission risk in these patients, the clinical value of XFC merits further promotion and investigation.

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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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