{"title":"印度东部的锰污染导致癌症风险。","authors":"Arun Kumar, Rajiv Kumar, Govind Kumar, Kanhaiya Kumar, Nirmal Kumar Chayal, Siddhant Aryal, Mukesh Kumar, Abhinav Srivastava, Mohammad Ali, Vivek Raj, Akhouri Bishwapriya, Muskan Manjari, Deepak Kumar, Santosh Kumar, Manisha Singh, Ashok Kumar Ghosh","doi":"10.1038/s41598-024-78478-0","DOIUrl":null,"url":null,"abstract":"<p><p>Groundwater poisoning by heavy metals has caused serious health hazards in the exposed population globally. Manganese (Mn) poisoning causing human health hazards is very meagerly reported worldwide. The present research elucidates for the first time the catastrophic effect of manganese causing cancer in the Gangetic plains of Bihar (India). The blood samples of n = 1146 cancer patients were voluntarily obtained for the study, after their consent. Their household water samples were also collected for the study. All the samples were analysed for Mn contamination by Atomic Absorption Spectrophotometer. The study indicates high Mn contamination in the cancer patient blood samples with highest content as 6022 µg/L. Moreover, the cancer patient's household handpump water samples also contained elevated Mn contamination. The correlation coefficient study finds significant association between Mn contamination in blood of cancer patients and their handpump water. The carcinoma group of cancer patients mostly in Stage III & IV had significant Mn contamination in their blood (above WHO/BIS permissible limit). The geospatial study depicts Mn contamination in handpump water in the state of Bihar in correlation with cancer patient's blood samples. This novel finding is being reported in India for the first time, which correlates cancer with handpump drinking water. The long-term Mn exposure could be one of the causative agents for elevating cancer incidences. 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Manganese (Mn) poisoning causing human health hazards is very meagerly reported worldwide. The present research elucidates for the first time the catastrophic effect of manganese causing cancer in the Gangetic plains of Bihar (India). The blood samples of n = 1146 cancer patients were voluntarily obtained for the study, after their consent. Their household water samples were also collected for the study. All the samples were analysed for Mn contamination by Atomic Absorption Spectrophotometer. The study indicates high Mn contamination in the cancer patient blood samples with highest content as 6022 µg/L. Moreover, the cancer patient's household handpump water samples also contained elevated Mn contamination. The correlation coefficient study finds significant association between Mn contamination in blood of cancer patients and their handpump water. The carcinoma group of cancer patients mostly in Stage III & IV had significant Mn contamination in their blood (above WHO/BIS permissible limit). The geospatial study depicts Mn contamination in handpump water in the state of Bihar in correlation with cancer patient's blood samples. This novel finding is being reported in India for the first time, which correlates cancer with handpump drinking water. The long-term Mn exposure could be one of the causative agents for elevating cancer incidences. 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引用次数: 0
摘要
重金属造成的地下水中毒对全球受影响人群的健康造成了严重危害。锰（Mn）中毒对人类健康造成危害的报道在全球范围内非常少。本研究首次阐明了锰对比哈尔邦（印度）恒河平原癌症的灾难性影响。本研究在征得 n = 1146 名癌症患者同意后，自愿采集了他们的血液样本。研究还采集了他们的家庭用水样本。采用原子吸收分光光度计对所有样本进行了锰污染分析。研究表明，癌症患者血液样本中的锰污染程度较高，最高含量为 6022 微克/升。此外，癌症患者的家用手泵水样本中的锰含量也很高。相关系数研究发现，癌症患者血液中的锰污染与他们的手泵水之间存在显著关联。癌症病人的癌症组大多处于第三和第四阶段，他们血液中的锰污染严重（高于世界卫生组织/国际清算银行的允许限值）。地理空间研究描述了比哈尔邦手泵水中的锰污染与癌症患者血液样本的相关性。这是印度首次报道癌症与手泵饮用水相关的新发现。长期接触锰可能是导致癌症发病率上升的原因之一。然而，也不能否认还有其他风险因素。
Manganese pollution in eastern India causing cancer risk.
Groundwater poisoning by heavy metals has caused serious health hazards in the exposed population globally. Manganese (Mn) poisoning causing human health hazards is very meagerly reported worldwide. The present research elucidates for the first time the catastrophic effect of manganese causing cancer in the Gangetic plains of Bihar (India). The blood samples of n = 1146 cancer patients were voluntarily obtained for the study, after their consent. Their household water samples were also collected for the study. All the samples were analysed for Mn contamination by Atomic Absorption Spectrophotometer. The study indicates high Mn contamination in the cancer patient blood samples with highest content as 6022 µg/L. Moreover, the cancer patient's household handpump water samples also contained elevated Mn contamination. The correlation coefficient study finds significant association between Mn contamination in blood of cancer patients and their handpump water. The carcinoma group of cancer patients mostly in Stage III & IV had significant Mn contamination in their blood (above WHO/BIS permissible limit). The geospatial study depicts Mn contamination in handpump water in the state of Bihar in correlation with cancer patient's blood samples. This novel finding is being reported in India for the first time, which correlates cancer with handpump drinking water. The long-term Mn exposure could be one of the causative agents for elevating cancer incidences. However, other confounding risk factors cannot be denied.
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