青少年内脏脂肪组织与肾小球高滤过率之间的关系：横断面研究

IF 1.3 4区医学 Q3 PEDIATRICS Archives De Pediatrie Pub Date : 2024-11-18 DOI:10.1016/j.arcped.2024.08.007

Yong-Chang Yang, Jing-Ying Zhao, Cheng-Guang Zhao

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引用次数: 0

摘要

目的：肾小球高滤过是肥胖相关肾小球疾病的早期指标。然而，在青少年中，还没有肥胖和肾小球高滤过率的量化指标。本研究调查了青少年内脏脂肪组织与肾小球高滤过率之间的关系：这项横断面研究使用了美国国家健康与营养调查（NHANES；2011-2018 年）的数据，纳入了 12-17 岁的青少年。内脏脂肪组织（VAT）和皮下脂肪组织（SAT）为自变量，估计肾小球滤过率（eGFR）为因变量。使用未调整和多变量回归分析以及亚组和交互分析评估了它们之间的关联：结果：多变量回归分析表明，增值税与青少年的 eGFR 和肾小球高滤过率呈正相关。VAT 每增加 100 克，男孩肾小球高滤过率增加 99%，女孩增加 56%。此外，男孩（β = 5.63，p < 0.001）和女孩（β = 2.72，p < 0.001）的脂肪体积与肾小球滤过率呈线性关系：结论：在 12-17 岁的美国青少年中，VAT 与 eGFR 和肾小球高滤过率呈正相关。

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Association between visceral adipose tissue and glomerular hyperfiltration in adolescents: A cross-sectional study.

Objective: Glomerular hyperfiltration is an early indicator of obesity-related glomerular disease. However, in adolescents, there are no quantifiable indicators of obesity and glomerular hyperfiltration. This study investigates the association between visceral adipose tissue and glomerular hyperfiltration in adolescents.

Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES; 2011-2018), and adolescents aged 12-17 years were included. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) formed the independent variables while estimated glomerular filtration rate (eGFR) acted as the dependent variable. Their association was assessed using unadjusted and multivariate regression analyses, as well as subgroup and interaction analyses.

Results: Multivariate regression analysis revealed that VAT was positively associated with eGFR and glomerular hyperfiltration among adolescents. The incidence of glomerular hyperfiltration increased by 99 % in boys and 56 % in girls per 100 g of VAT increase. Additionally, VAT and eGFR exhibited a linear relationship in both boys (β = 5.63, p < 0.001) and girls (β = 2.72, p < 0.001).

Conclusions: In US adolescents aged 12-17 years, VAT was positively correlated with eGFR and glomerular hyperfiltration.

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来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.