用于放射治疗的质子束布拉格峰修正技术

IF 0.4 Q4 PHYSICS, PARTICLES & FIELDS Physics of Particles and Nuclei Letters Pub Date : 2024-11-22 DOI:10.1134/S1547477124701747
A. A. Abduvaliev, A. V. Agapov, V. M. Breev, G. V. Mytsin, J. H. Khushvaktov, S. S. Uglova, K. N. Shipulin
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引用次数: 0

摘要

日本放射研究所与位于圣彼得堡的埃夫列莫夫电子物理装置研究所(NIIEFA)合作,正在开发超导等速回旋加速器 MSC230,该加速器旨在开展放射生物学研究,并开发质子闪光放射治疗技术。为此,研究人员探讨了在新加速器中形成高强度质子束的问题,该质子束的能量可在 120-230 兆电子伏范围内选择,剂量率为 50-100 Gy/s,截面均匀,直径为 13-15 厘米。本文介绍了蒙特卡洛法建模和质子束深度-剂量分布测量的结果,质子束的能谱经过修改,在量程末端获得了一个扩展的均质高原(扩散的布拉格峰)。这是通过使用所谓的脊滤波器实现的。文中介绍了一种使用 3D 打印机设计和制造脊状滤波器的方法,通过相对于光束轴线的旋转,可以在相当宽的数值范围内改变高原的长度。研究结果表明,两套滤波器(每套由 5-6 个这样的滤波器组成)有望跨越布拉格峰高原所需的整个范围,并适用于所有选定的能量值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Technique of Modification of the Bragg Peak of a Proton Beam for Radiotherapy

JINR in collaboration with the St. Petersburg-based Efremov Institute of Electrophysical Apparatus (NIIEFA) is developing a superconducting isochronous cyclotron MSC230, which is intended to conduct research in radiobiology and to develop proton flash radiotherapy techniques. In relation to this, formation of a high-intensity proton beam with the energy selectable in a range of 120–230 MeV, a dose rate of 50–100 Gy/s, and homogeneous in cross section with a diameter of 13–15 cm at the new accelerator is explored. Results of modeling by the Monte Carlo method and measurements of the depth-dose distributions of a proton beam, the energy spectrum of which is modified to obtain an extended homogeneous plateau at the end of the range (spread-out Bragg peak), are presented. This is achieved by using so-called ridge filters. A method for design and manufacturing ridge filters using a 3D printer that can change the length of the plateau in a fairly wide range of values by rotating it relative to the beam axis is presented. The results of the study lend a hope that two sets, each consisting of 5–6 such filters, will be able to span the entire required range of the Bragg peak plateau, and for all values of the selected energy.

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来源期刊
Physics of Particles and Nuclei Letters
Physics of Particles and Nuclei Letters PHYSICS, PARTICLES & FIELDS-
CiteScore
0.80
自引率
20.00%
发文量
108
期刊介绍: The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.
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