I. A. Zamulaeva, O. N. Matchuk, E. I. Selivanova, V. A. Mosina, M. R. Abramova, V. O. Saburov, S. N. Koryakin, S. A. Ivanov, A. D. Kaprin, A. V. Boreyko, V. N. Chausov, E. A. Krasavin
{"title":"分段质子辐照联合 1-β-D-Arabinofuranosylcytosine 对体内 B16 小鼠黑色素瘤的影响","authors":"I. A. Zamulaeva, O. N. Matchuk, E. I. Selivanova, V. A. Mosina, M. R. Abramova, V. O. Saburov, S. N. Koryakin, S. A. Ivanov, A. D. Kaprin, A. V. Boreyko, V. N. Chausov, E. A. Krasavin","doi":"10.1134/S1547477124701784","DOIUrl":null,"url":null,"abstract":"<p>This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (<i>p</i> < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"21 6","pages":"1208 - 1218"},"PeriodicalIF":0.4000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo\",\"authors\":\"I. A. Zamulaeva, O. N. Matchuk, E. I. Selivanova, V. A. Mosina, M. R. Abramova, V. O. Saburov, S. N. Koryakin, S. A. Ivanov, A. D. Kaprin, A. V. Boreyko, V. N. Chausov, E. A. Krasavin\",\"doi\":\"10.1134/S1547477124701784\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (<i>p</i> < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.</p>\",\"PeriodicalId\":730,\"journal\":{\"name\":\"Physics of Particles and Nuclei Letters\",\"volume\":\"21 6\",\"pages\":\"1208 - 1218\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics of Particles and Nuclei Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1547477124701784\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, PARTICLES & FIELDS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics of Particles and Nuclei Letters","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S1547477124701784","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, PARTICLES & FIELDS","Score":null,"Total":0}
Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo
This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.
期刊介绍：
The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
