Nathan P Wiederhold, Hoja P Patterson, Dora Ferrer, Victor Garcia, George R Thompson, Thomas F Patterson
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引用次数: 0
摘要
我们评估了 Olorofim 对球孢子菌的体外活性。奥罗菲姆对所有受试分离菌株都表现出了很强的体外活性，其最低抑菌浓度（MIC）范围≤0.008-0.06 µg/mL，几何平均MIC为0.010 µg/mL。对于氟康唑 MIC 值较高（≥16 µg/mL）的分离菌株，包括 MIC 值≥32 µg/mL（奥洛菲 MIC 值范围≤0.008-0.06 µg/mL，几何平均 MIC 值分别为≤0.009 和≤0.013 µg/mL）的菌株，也能保持这种活性。
Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity.
We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).
期刊介绍：
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
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