Thomas S Przybycien, Kimberly Gray, Sameer Sidiq, Sandra Mihail, Tam T Doan, Shagun Sachdeva, Dana Reaves-O'Neal, Ziyad Binsalamah, Silvana Molossi
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Total cholesterol, HDL, LDL, triglycerides, total cholesterol to HDL ratio, and non-HDL cholesterol were evaluated across race/ethnicity, sex, type of AAOCA, documented ischaemia on imaging, exercise level, and surgery status. Normality of the data distribution for each lipid parameter was evaluated using Kolmogorov-Smirnov testing. Accordingly, Mann-Whitney U and t-tests were used to compare variables. The proportion of abnormal lipid levels by sex and race/ethnicity was calculated.</p><p><strong>Results: </strong>Total cholesterol was elevated in 29%, (51/177) of patients, HDL 37% (64/174), triglycerides 44% (72/165), LDL 16% (28/170), total cholesterol-HDL ratio 29%, (48/163), and non-HDL cholesterol 28% (47/165). Across subgroups categorised on the basis of surgery status, exercise level, AAOCA type, and sex, the mean and median levels for individual lipid parameters were normal. By race/ethnicity, Hispanic patients had significantly higher triglyceride (median 99, interquartile range 71-136.5, <i>p</i> = <0.001) and total cholesterol to HDL ratios (median 3.2, interquartile range 2.7-4.5, <i>p</i> = 0.014) versus non-Hispanic White and Black patients. Two-thirds of patients exercise recreationally.</p><p><strong>Conclusion: </strong>Hispanic patients have significantly elevated triglycerides and total cholesterol to HDL ratios compared to others. Longitudinal follow-up evaluating differences in long-term lipid status in patients with AAOCA and risk for cardiovascular events is warranted.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1-6"},"PeriodicalIF":0.9000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterising the lipid profile of paediatric patients with anomalous aortic origins of a coronary artery.\",\"authors\":\"Thomas S Przybycien, Kimberly Gray, Sameer Sidiq, Sandra Mihail, Tam T Doan, Shagun Sachdeva, Dana Reaves-O'Neal, Ziyad Binsalamah, Silvana Molossi\",\"doi\":\"10.1017/S1047951124035996\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Lipid levels in paediatric patients with anomalous aortic origin of a coronary artery (AAOCA) have not previously been explored. Patients with CHD have an increased risk of atherosclerotic cardiovascular disease later in life compared to the general population. We aim to characterise the lipid profiles in paediatric patients with AAOCA and explore its relation to diagnosis, race/ethnicity, and exercise.</p><p><strong>Methods: </strong>Single institution retrospective cohort of 180 AAOCA paediatric patients (median age 13.7 years interquartile range 9.7-15.6, 66% male). Total cholesterol, HDL, LDL, triglycerides, total cholesterol to HDL ratio, and non-HDL cholesterol were evaluated across race/ethnicity, sex, type of AAOCA, documented ischaemia on imaging, exercise level, and surgery status. Normality of the data distribution for each lipid parameter was evaluated using Kolmogorov-Smirnov testing. Accordingly, Mann-Whitney U and t-tests were used to compare variables. The proportion of abnormal lipid levels by sex and race/ethnicity was calculated.</p><p><strong>Results: </strong>Total cholesterol was elevated in 29%, (51/177) of patients, HDL 37% (64/174), triglycerides 44% (72/165), LDL 16% (28/170), total cholesterol-HDL ratio 29%, (48/163), and non-HDL cholesterol 28% (47/165). Across subgroups categorised on the basis of surgery status, exercise level, AAOCA type, and sex, the mean and median levels for individual lipid parameters were normal. By race/ethnicity, Hispanic patients had significantly higher triglyceride (median 99, interquartile range 71-136.5, <i>p</i> = <0.001) and total cholesterol to HDL ratios (median 3.2, interquartile range 2.7-4.5, <i>p</i> = 0.014) versus non-Hispanic White and Black patients. Two-thirds of patients exercise recreationally.</p><p><strong>Conclusion: </strong>Hispanic patients have significantly elevated triglycerides and total cholesterol to HDL ratios compared to others. Longitudinal follow-up evaluating differences in long-term lipid status in patients with AAOCA and risk for cardiovascular events is warranted.</p>\",\"PeriodicalId\":9435,\"journal\":{\"name\":\"Cardiology in the Young\",\"volume\":\" \",\"pages\":\"1-6\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiology in the Young\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S1047951124035996\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiology in the Young","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S1047951124035996","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
背景:以前从未研究过冠状动脉主动脉起源异常(AAOCA)儿科患者的血脂水平。与普通人群相比,患有先天性心脏病的患者日后罹患动脉粥样硬化性心血管疾病的风险更高。我们旨在描述 AAOCA 儿科患者的血脂特征,并探讨其与诊断、种族/民族和运动的关系:180 名 AAOCA 儿科患者(中位年龄 13.7 岁,四分位距 9.7-15.6 岁,66% 为男性)的单机构回顾性队列。对不同种族/民族、性别、AAOCA 类型、影像记录缺血、运动水平和手术状态的总胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯、总胆固醇与高密度脂蛋白比率和非高密度脂蛋白胆固醇进行了评估。采用 Kolmogorov-Smirnov 检验法评估了各血脂参数数据分布的正态性。因此,在比较变量时使用了曼-惠特尼 U 检验和 t 检验。计算了不同性别和种族/族裔的血脂异常比例:结果:29%(51/177)的患者总胆固醇升高,37%(64/174)的患者高密度脂蛋白升高,44%(72/165)的患者甘油三酯升高,16%(28/170)的患者低密度脂蛋白升高,29%(48/163)的患者总胆固醇-高密度脂蛋白比值升高,28%(47/165)的患者非高密度脂蛋白胆固醇升高。在根据手术状况、运动水平、AAOCA 类型和性别划分的亚组中,各项血脂参数的平均值和中位值均正常。按种族/人种划分,西班牙裔患者的甘油三酯(中位数 99,四分位距 71-136.5,p = p = 0.014)明显高于非西班牙裔白人和黑人患者。三分之二的患者进行娱乐性锻炼:结论:与其他人相比,西班牙裔患者的甘油三酯和总胆固醇与高密度脂蛋白的比率明显升高。有必要进行纵向随访,评估 AAOCA 患者长期血脂状况的差异以及心血管事件的风险。
Characterising the lipid profile of paediatric patients with anomalous aortic origins of a coronary artery.
Background: Lipid levels in paediatric patients with anomalous aortic origin of a coronary artery (AAOCA) have not previously been explored. Patients with CHD have an increased risk of atherosclerotic cardiovascular disease later in life compared to the general population. We aim to characterise the lipid profiles in paediatric patients with AAOCA and explore its relation to diagnosis, race/ethnicity, and exercise.
Methods: Single institution retrospective cohort of 180 AAOCA paediatric patients (median age 13.7 years interquartile range 9.7-15.6, 66% male). Total cholesterol, HDL, LDL, triglycerides, total cholesterol to HDL ratio, and non-HDL cholesterol were evaluated across race/ethnicity, sex, type of AAOCA, documented ischaemia on imaging, exercise level, and surgery status. Normality of the data distribution for each lipid parameter was evaluated using Kolmogorov-Smirnov testing. Accordingly, Mann-Whitney U and t-tests were used to compare variables. The proportion of abnormal lipid levels by sex and race/ethnicity was calculated.
Results: Total cholesterol was elevated in 29%, (51/177) of patients, HDL 37% (64/174), triglycerides 44% (72/165), LDL 16% (28/170), total cholesterol-HDL ratio 29%, (48/163), and non-HDL cholesterol 28% (47/165). Across subgroups categorised on the basis of surgery status, exercise level, AAOCA type, and sex, the mean and median levels for individual lipid parameters were normal. By race/ethnicity, Hispanic patients had significantly higher triglyceride (median 99, interquartile range 71-136.5, p = <0.001) and total cholesterol to HDL ratios (median 3.2, interquartile range 2.7-4.5, p = 0.014) versus non-Hispanic White and Black patients. Two-thirds of patients exercise recreationally.
Conclusion: Hispanic patients have significantly elevated triglycerides and total cholesterol to HDL ratios compared to others. Longitudinal follow-up evaluating differences in long-term lipid status in patients with AAOCA and risk for cardiovascular events is warranted.
期刊介绍:
Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. By design, the journal is international and multidisciplinary in its approach, and members of the editorial board take an active role in the its mission, helping to make it the essential journal in paediatric cardiology. All aspects of paediatric cardiology are covered within the journal. The content includes original articles, brief reports, editorials, reviews, and papers devoted to continuing professional development.