球虫脑膜炎患者药物基因组学检测的临床实用性。

IF 2.7 3区医学 Q3 INFECTIOUS DISEASES Medical mycology Pub Date : 2024-11-20 DOI:10.1093/mmy/myae113

Rawan Elkurdi, Marie F Grill, Adrijana Kekic, Janis E Blair

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引用次数: 0

摘要

球孢子菌病可导致严重的脑膜炎，需要终生治疗。在这项研究中，我们试图更好地了解药物基因组学检测对球虫脑膜炎患者治疗结果的潜在影响。在接受药物基因组学检测的13名球虫脑膜炎患者中，有11人的CYP2C19和CYP3A5基因变异会影响抗真菌药物的疗效。这些结果导致了治疗方法的实时改变和未来的抗真菌规划。常规药物基因组学检测有助于避免无效或导致不良反应的抗真菌治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical utility of pharmacogenomic testing for patients with coccidioidal meningitis.

Coccidioidomycosis can cause severe meningitis requiring lifelong treatment. In this study, we sought to better understand the potential effect of pharmacogenomic testing on treatment outcomes of patients with coccidioidal meningitis. Of 13 patients with coccidioidal meningitis who underwent pharmacogenomic testing, 11 had genetic variants of CYP2C19 and CYP3A5 that affect antifungal efficacy. These results led to real-time treatment changes and future antifungal planning. Routine pharmacogenomic testing helps to avoid antifungal treatments that are futile or lead to adverse effects.

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.