{"title":"内源性逆转录病毒的失调会引发衰老和衰老。","authors":"Jill A. Kreiling","doi":"10.1038/s43587-024-00759-0","DOIUrl":null,"url":null,"abstract":"A study by Mao, Zhang, Zhuang and colleagues defines a specific class of endogenous retroviruses that are upregulated with age and in cellular senescence by the stress-induced transcription factor ATF3. The expression of endogenous retroviral elements has implications for the development of inflammation that may drive the onset of aging pathologies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1670-1672"},"PeriodicalIF":19.4000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dysregulation of endogenous retroviruses triggers aging and senescence\",\"authors\":\"Jill A. Kreiling\",\"doi\":\"10.1038/s43587-024-00759-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A study by Mao, Zhang, Zhuang and colleagues defines a specific class of endogenous retroviruses that are upregulated with age and in cellular senescence by the stress-induced transcription factor ATF3. The expression of endogenous retroviral elements has implications for the development of inflammation that may drive the onset of aging pathologies.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"4 12\",\"pages\":\"1670-1672\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00759-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00759-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Dysregulation of endogenous retroviruses triggers aging and senescence
A study by Mao, Zhang, Zhuang and colleagues defines a specific class of endogenous retroviruses that are upregulated with age and in cellular senescence by the stress-induced transcription factor ATF3. The expression of endogenous retroviral elements has implications for the development of inflammation that may drive the onset of aging pathologies.
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