通过顺序[3 + 2]嵌合和[3,3]对称重排合成苯并氮杂卓

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-11-22 DOI:10.1021/acs.orglett.4c03543

Fang Luo, Wei Wang, Chaowei Xiang, Linghui Zeng, Chong Zhang, Jiankang Zhang, Xingxian Zhang, Jiaan Shao, Huajian Zhu

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引用次数: 0

摘要

研究人员开发了一种丙-2-炔基磺鎓盐与硫酰化物和亚硝基苯的新型环化反应，以中等至良好的收率获得了各种苯并氮杂卓。丙-2-炔基锍盐在反应中充当了 C3 合子的角色，利用容易获得的起始原料，通过单锅操作提供了一种很有前景的苯并氮杂卓骨架。

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The Synthesis of Benzazepines via Sequential [3 + 2]-Annulation and [3,3]-Sigmatropic Rearrangement

A novel annulation reaction of prop-2-ynylsulfonium salts with sulfur ylides and nitrosobenzenes has been developed, affording various benzazepines in moderate to good yields. Prop-2-ynylsulfonium salts act as C₃ synthons in the reactions, providing a promising benzazepine skeleton in a one-pot operation with readily accessible starting materials.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.