通过解构-再解构策略催化环丙烷的合作光氧化和 N-杂环羰基正式 C-H 酰化反应

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Science Pub Date : 2024-11-22 DOI:10.1039/d4sc06355d

Fan Gao, Tian Wang, Xiaoyu Yan

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引用次数: 0

摘要

环丙烷无处不在，是市售药物和生物活性分子的关键结构基团。在此，我们介绍了在光氧化和 N-杂环碳烯协同催化下芳基环丙烷的区域选择性酰化。这种方法涉及通过γ-氯酮作为中间体的解构-重构策略，并实现了环丙烷的正式 C(sp3)-H 功能化。

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Cooperative Photoredox and N-Heterocyclic Carbene-Catalyzed Formal C-H Acylation of Cyclopropanes via Deconstruction-Reconstruction Strategy

Cyclopropanes are ubiquitous and key structural motifs in commercially available drugs and bioactive molecules. Herein, we present regio-selective acylation of aryl cyclopropanes with cooperative photoredox and N-heterocyclic carbene catalysis. This approach involves deconstruction-reconstruction strategy via γ-chloro-ketones as intermediates and fulfills the formal C(sp3)−H functionalization of cyclopropanes.

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.