光诱导 α-重氮羰基化合物向单取代α-卤素衍生物的转化。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-11-22 DOI:10.1039/d4ob01641f

Jinrui Bai, Bin Li, Dan Qi, Zhuoheng Song, Yue Yao, Chao Liu

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引用次数: 0

摘要

本文报告了在光诱导条件下重氮化合物与三种新型卤化剂的氢卤化反应。该方法无需加热、过渡金属催化剂或光催化剂，即可实现氢氟化、氢氯化和氢溴化反应（共 56 例，最高制备收率为 94%），并且具有广泛的底物范围。值得注意的是，利用连续流反应器进行了克级合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photo-induced transformation of α-diazocarbonyl compounds into mono-substituted alpha-halogen derivatives.

Herein, the hydrogen halogenation reaction of diazo compounds with three new halogenating agents under photoinduced conditions is reported. This method realized hydrofluorination, hydrochlorination, and hydrobromination (56 cases in total, with the highest preparative yield of 94%) without requiring heating, transition metal catalysts or photocatalysts and exhibits a broad substrate scope. Notably, gram-scale synthesis using a continuous flow reactor was performed.

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