Özlem Kılıç, Duygu Tecer, Muhammed Canbaş, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz
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引用次数: 0
摘要
目的：本研究旨在评估类风湿关节炎（RA）免疫营养指数与疾病活动性之间的关系：本研究对 90 名年龄与性别匹配的健康对照者和 116 名符合 2010 年美国风湿病学会和欧洲抗风湿联盟分类标准的 RA 患者进行了横断面分析。患者被分为缓解期（疾病活动度评分 28-红细胞沉降率（DAS 28-ESR) 结果：RA组的全身免疫炎症指数（SII）、控制营养状况（CONUT）和纤维蛋白原白蛋白比值（FAR）均高于对照组，而RA组的CRP-白蛋白-淋巴细胞比值（CALLY）和预后营养指数（PNI）则明显低于对照组（p p p p 结论：CALLY和PNI可能会对RA患者的病情产生影响：CALLY和PNI可能是评估RA患者疾病活动性的有用预后指标。
Immune nutrition indices are associated with disease activity in rheumatoid arthritis: a cross-sectional study.
Aim: This study aimed to evaluate the relationship between immune nutrition indices and disease activity in rheumatoid arthritis (RA).
Methods: The current study included a cross-sectional analysis of 90 age and gender-matched healthy controls and 116 RA patients who satisfied the 2010 American College of Rheumatology and European League Against Rheumatism categorization criteria. Patients were categorized into remission (disease activity score 28- erythrocyte sedimentation rate (DAS 28-ESR) <2.6) and active disease (DAS 28-ESR ≥2.6) groups.
Results: Systemic immune-inflammatory index (SII), controlling nutritional status (CONUT), and fibrinogen-to-albumin ratio (FAR) were higher in the RA group than in controls, whereas CRP-albumin-lymphocyte ratio (CALLY) and prognostic nutrition index (PNI) were considerably lower in RA (p < 0.001). The clinical and simplified disease activity index, DAS 28-ESR had negative correlation with PNI and CALLY (p < 0.001). PNI and CALLY were independently related markers of disease activity (p < 0.001) by regression analysis. According to receiver operating characteristic curve analysis, the ideal cutoff values for the active disease are as follows: CONUT, 0.5; CALLY, 12.5, SII, 579.43, FAR, 90.43, and PNI, 40. CALLY was the most sensitive (84.06%) and specific marker (95.74%).
Conclusions: CALLY and PNI may be useful prognostic markers for assessing disease activity in RA patients.
期刊介绍：
Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory.
Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice.
As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications.
Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest.
Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.
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