L N Tikhomirova, Yu S Medvedeva, M A Lebedeva, I Yu Gavrilov, S V Revenko, M Yu Karganov, E G Popov, I A Tarakanov
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The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ.
The rheographic parameters of the segments of brachial and femoral arteries were measured in situ after a 14-day-long hindlimb unloading (HU) of rats. HU significantly increased electrical impedance Z of a segment of femoral artery indicating its constriction; in parallel, HU resulted in a decreasing trend of Z of a segment of brachial artery attesting to its dilation. In both arteries, HU significantly or as a trend decreased the swing ranges of active and passive pulsations, respectively. BP reduction during bloodletting induced transition from passive to active pulsatile mode in the femoral artery only in 33% experimental rats in contrast to 87% control ones. We suppose that degradation of active pulsatile mode is responsible for the negative influences of microgravity and weightlessness on blood circulation. The study determined the rheographic parameters that reliably reflect changes in the functional activity of arteries after chronic redistribution of hydrostatic load.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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