{"title":"Emboless® 静脉腔能有效减少气泡：一项针对慢性血液透析患者的随机研究。","authors":"Ulf Forsberg, Per Jonsson, Bernd Stegmayr","doi":"10.1093/ckj/sfae323","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>When blood passes the extracorporeal circuit, air microbubbles (MBs) contaminate the blood. Some MBs will end up as microemboli in the lung, heart, and brain. MB exposure has no medical purpose and is considered to be bio-incompatible. Selecting venous chambers with a high removal rate of MBs is warranted to reduce the risks of air bio-incompatibility. The primary aim was to compare the Fresenius 5008 (F5008-VC) and the Emboless<sup>®</sup> (Emboless-VC) venous chambers regarding the elimination of MBs in the return bloodline during hemodialysis (HD).</p><p><strong>Methods: </strong>Twenty patients underwent 80 sessions of cross-over HD using both the F5008-VC and the Emboless-VC randomized such that half started with the F5008-VC and half with the Emboless-VC. For 32 of the 80 sessions, measurements were also performed during hemodiafiltrations (HDF) after the initial HD. MBs were measured with an ultrasound device (within the size range of 20-500 µm) at the \"inlet\" and \"outlet\" bloodline of the venous chambers. The Wilcoxon pairwise test compared the percentage of MB elimination between venous chambers.</p><p><strong>Results: </strong>During HD, the median reduction of MBs for the outlet was 39% with the F5008-VC and 76% with the Emboless-VC (<i>P </i>< .001). During HDF, the reduction was 28% with the F5008-VC and 70% with the Emboless-VC (<i>P </i>< .001).</p><p><strong>Conclusion: </strong>Fewer MBs and subsequently fewer microemboli entered the bloodline of the patient using the Emboless-VC compared to the F5008-VC venous chamber during HD and during HDF. Venous chambers with a high removal rate of MBs will reduce the extent of air emboli.</p>","PeriodicalId":10435,"journal":{"name":"Clinical Kidney Journal","volume":"17 11","pages":"sfae323"},"PeriodicalIF":3.9000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579606/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Emboless® venous chamber efficiently reduces air bubbles: a randomized study of chronic hemodialysis patients.\",\"authors\":\"Ulf Forsberg, Per Jonsson, Bernd Stegmayr\",\"doi\":\"10.1093/ckj/sfae323\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>When blood passes the extracorporeal circuit, air microbubbles (MBs) contaminate the blood. Some MBs will end up as microemboli in the lung, heart, and brain. MB exposure has no medical purpose and is considered to be bio-incompatible. Selecting venous chambers with a high removal rate of MBs is warranted to reduce the risks of air bio-incompatibility. The primary aim was to compare the Fresenius 5008 (F5008-VC) and the Emboless<sup>®</sup> (Emboless-VC) venous chambers regarding the elimination of MBs in the return bloodline during hemodialysis (HD).</p><p><strong>Methods: </strong>Twenty patients underwent 80 sessions of cross-over HD using both the F5008-VC and the Emboless-VC randomized such that half started with the F5008-VC and half with the Emboless-VC. For 32 of the 80 sessions, measurements were also performed during hemodiafiltrations (HDF) after the initial HD. MBs were measured with an ultrasound device (within the size range of 20-500 µm) at the \\\"inlet\\\" and \\\"outlet\\\" bloodline of the venous chambers. The Wilcoxon pairwise test compared the percentage of MB elimination between venous chambers.</p><p><strong>Results: </strong>During HD, the median reduction of MBs for the outlet was 39% with the F5008-VC and 76% with the Emboless-VC (<i>P </i>< .001). During HDF, the reduction was 28% with the F5008-VC and 70% with the Emboless-VC (<i>P </i>< .001).</p><p><strong>Conclusion: </strong>Fewer MBs and subsequently fewer microemboli entered the bloodline of the patient using the Emboless-VC compared to the F5008-VC venous chamber during HD and during HDF. Venous chambers with a high removal rate of MBs will reduce the extent of air emboli.</p>\",\"PeriodicalId\":10435,\"journal\":{\"name\":\"Clinical Kidney Journal\",\"volume\":\"17 11\",\"pages\":\"sfae323\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-10-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579606/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Kidney Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ckj/sfae323\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Kidney Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ckj/sfae323","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
The Emboless® venous chamber efficiently reduces air bubbles: a randomized study of chronic hemodialysis patients.
Background: When blood passes the extracorporeal circuit, air microbubbles (MBs) contaminate the blood. Some MBs will end up as microemboli in the lung, heart, and brain. MB exposure has no medical purpose and is considered to be bio-incompatible. Selecting venous chambers with a high removal rate of MBs is warranted to reduce the risks of air bio-incompatibility. The primary aim was to compare the Fresenius 5008 (F5008-VC) and the Emboless® (Emboless-VC) venous chambers regarding the elimination of MBs in the return bloodline during hemodialysis (HD).
Methods: Twenty patients underwent 80 sessions of cross-over HD using both the F5008-VC and the Emboless-VC randomized such that half started with the F5008-VC and half with the Emboless-VC. For 32 of the 80 sessions, measurements were also performed during hemodiafiltrations (HDF) after the initial HD. MBs were measured with an ultrasound device (within the size range of 20-500 µm) at the "inlet" and "outlet" bloodline of the venous chambers. The Wilcoxon pairwise test compared the percentage of MB elimination between venous chambers.
Results: During HD, the median reduction of MBs for the outlet was 39% with the F5008-VC and 76% with the Emboless-VC (P < .001). During HDF, the reduction was 28% with the F5008-VC and 70% with the Emboless-VC (P < .001).
Conclusion: Fewer MBs and subsequently fewer microemboli entered the bloodline of the patient using the Emboless-VC compared to the F5008-VC venous chamber during HD and during HDF. Venous chambers with a high removal rate of MBs will reduce the extent of air emboli.
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Clinical Kidney Journal: Clinical and Translational Nephrology (ckj), an official journal of the ERA-EDTA (European Renal Association-European Dialysis and Transplant Association), is a fully open access, online only journal publishing bimonthly. The journal is an essential educational and training resource integrating clinical, translational and educational research into clinical practice. ckj aims to contribute to a translational research culture among nephrologists and kidney pathologists that helps close the gap between basic researchers and practicing clinicians and promote sorely needed innovation in the Nephrology field. All research articles in this journal have undergone peer review.
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