Chemical mixtures of mercury, PCBs, PFAS/PFOS, and pesticides in freshwater fish in the US and the risks they pose for fish consumption.

Background: Freshwater fish are important food sources that also pose risks to human and wildlife health because of the bioaccumulation of environmental chemicals in their tissues. Although most studies, fish consumption advisories, and regulations focus on individual contaminants, fish consumers are exposed to mixtures of chemicals, including legacy contaminants and contaminants of emerging concern, that can have combined effects. Chemicals of emerging concern represent one source of hazard, but legacy contaminants can still pose threats to fish consumers due to their persistence in the environment.

Objectives: We investigate the following questions: 1) Do different chemicals correlate with one another in fish tissue, and if so, how? 2) How do levels of different chemicals in fish tissue vary by time and location? and 3) How do observed chemical levels compare with risk-based screening levels?

Methods: Using several national data sources established and maintained by the US Environmental Protection Agency (NRSA, NCCA-GL, GLENDA, and NLFTS), this study examines the co-occurrence of chemicals in freshwater fish in lakes, ponds, streams, and rivers in the US.

Results: We determine that organic contaminants correlate with one another, but generally not with mercury; organic chemicals have declined over time, but mercury has not; and fish concentrations of legacy contaminants-even those banned for decades-continue to exceed risk-based screening levels.

Discussion: Despite some successes in curtailing release of pollutants, some contaminants in fish tissue have not declined and legacy and emerging pollutants continue to pose risks to fish consumers in the US. Correlations between chemicals in fish tissue suggest that exposures to mixtures is prevalent in the US but that organic contaminants do not generally correlate with mercury-noteworthy particularly since fish consumption advisories in the US are frequently driven by the level of mercury, and do not account for exposure to multiple contaminants. While programs such as the National Aquatic Resource Surveys (NARS) Program seek to systematically monitor contaminants in fish tissue and other environmental indicators, continuous support from the US federal government is required to sustain this monitoring. Moreover, greater legislative and regulatory efforts are required at both the state and federal levels to reduce continuing sources and ongoing contamination.