Aaron Earl Hodgson, Yurii Shepelytskyi, Viktoriia Batarchuk, Nedal Al Taradeh, Vira Grynko, Mitchell S Albert
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引用次数: 0
摘要
目的:提高磁共振成像(MRI)的灵敏度对其作为一种成像方式的发展至关重要。开发用于有效射频磁场聚焦的无源伦茨谐振器将通过局部放大磁共振成像信号来提高磁共振成像的灵敏度,从而提高诊断和治疗病人的效率:虽然有一些方法可以放大磁共振成像中特定细胞核的信号,如超极化,但通用解决方案将更具优势,并能与这些现有方法结合使用。虽然伦兹透镜根据伦兹定律和互惠原理提出了这样一种通用解决方案,但其代价是信号增强效果有限。在这项工作中,我们构思并研究了首个原型伦兹谐振器,将其作为一种通用的频率选择性被动磁通聚焦元件,以显著增强磁共振成像信号。我们使用 3.0 T 飞利浦 Achieva 核磁共振成像仪,比较了在使用伦茨透镜、伦茨谐振器和对照试验中均未使用这两种元件的情况下模型的信号:一项磁共振成像研究表明,由于 B1 磁场聚焦效果出色,使用两个同轴伦茨谐振器的磁共振成像插件可将信噪比放大至 80%。谐振器显示出一致的放大效果,几乎与它们在核磁共振成像孔内的 x 位置无关:意义:这证明了使用伦茨谐振器对不同形状的大型物体进行成像而不影响信号放大的可行性。伦茨谐振器在几何设计上的多样性和不同脉冲序列之间一致的信号放大能力,使得伦茨谐振器的开发适用于大多数常用的磁共振成像装置。
Novel frequency selective B1focusing passive Lenz resonators for substantial MRI signal-to-noise ratio amplification.
Objective: The need for increased sensitivity in magnetic resonance imaging (MRI) is crucial for its advancement as an imaging modality. The development of passive Lenz Resonators for effective RF magnetic field focusing will improve MRI sensitivity via local amplification of MRI signal, thereby leading to more efficient diagnosis and patient treatment.
Approach: While there are methods for amplifying the signal from specific nuclei in MRI, such as hyperpolarization, a general solution will be more advantageous and would work in combination with these preexisting methods. While the Lenz Lens proposed such a general solution based on Lenz's law and the reciprocity principle, it came at the cost of limited signal enhancement. In this work, the first-in-kind prototype Lenz Resonator was conceived and examined as a general frequency-selective passive flux-focusing element for significant MRI signal enhancement. A 3.0 T Philips Achieva MRI was used to compare the signal from a phantom in the presence of Lenz Lenses, Lenz Resonators, and control trials with neither component.
Main results: An MRI investigation demonstrated an experimental amplification of the signal-to-noise ratio up to 80% using an MRI insert of two coaxial Lenz Resonators due to superior B1 magnetic field focusing. The resonators displayed consistent amplification, nearly independent of their x-position within the MRI bore.
Significance: This behavior demonstrates the feasibility of imaging large objects of varying shapes without penalties for signal amplification using Lenz Resonators. The Lenz Resonators versatility in geometrical design and consistent signal amplifying abilities between pulse sequences should allow for the development of Lenz Resonators suitable for most commonly used MRI setups.
期刊介绍:
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry