Jie Yin , Dong Huang , Jianzhao Zhang , Rongxu Zhang , Shuming Zhong , Jiali He , Yangyu Wu , Shijie Luo , Jingyan Sun , Yitong Liu , Xiaodong Song , Shunkai Lai , Yanli Gao , Zhao Chen , Yanbin Jia
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Plasma levels of adrenocorticotropic hormone (ACTH), cortisol (CORT), testosterone (T), and prolactin (PRL) were measured in all patients. Suicidal ideation was assessed by item 3 of the Hamilton Depression Rating Scale.</div></div><div><h3>Results</h3><div>In adolescents, plasma T levels were higher in MDD than in BD (<em>p</em>=0.018), MDD patients with suicidal ideation exhibited higher T levels than BD patients with suicidal ideation (<em>p</em>=0.036), and plasma T levels were associated with diagnosis (OR<sub>adjus</sub>=0.777, <em>p</em>=0.023). In adults, plasma ACTH levels were elevated in MDD versus BD (<em>p</em>=0.012) and were also diagnosis-related (OR<sub>adjus</sub>=0.972, <em>p</em>=0.019). Plasma levels of other hormones were not significantly different between MDD and BD in adolescents or adults (all <em>p</em>>0.05).</div></div><div><h3>Conclusions</h3><div>There was an age-specific difference in the T and ACTH between depressed patients with MDD and BD. Suicidal ideation was linked to T in adolescents.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107227"},"PeriodicalIF":3.4000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The differences in testosterone and stress hormones between unipolar and bipolar depression in adolescents and adults\",\"authors\":\"Jie Yin , Dong Huang , Jianzhao Zhang , Rongxu Zhang , Shuming Zhong , Jiali He , Yangyu Wu , Shijie Luo , Jingyan Sun , Yitong Liu , Xiaodong Song , Shunkai Lai , Yanli Gao , Zhao Chen , Yanbin Jia\",\"doi\":\"10.1016/j.psyneuen.2024.107227\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>While patients with major depressive disorder (MDD) and bipolar disorder (BD) often exhibit aberrant hormones, it is still unknown whether the hormones differ between MDD and BD across the age spectrum. We aimed to investigate the differences in testosterone and stress hormones between depressed patients with MDD and BD in adolescents and adults, and the impact of suicidal ideation on these.</div></div><div><h3>Methods</h3><div>A total of 432 depressed patients (270 MDD and 162 BD) were recruited, including 177 adolescents and 255 adults. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol (CORT), testosterone (T), and prolactin (PRL) were measured in all patients. Suicidal ideation was assessed by item 3 of the Hamilton Depression Rating Scale.</div></div><div><h3>Results</h3><div>In adolescents, plasma T levels were higher in MDD than in BD (<em>p</em>=0.018), MDD patients with suicidal ideation exhibited higher T levels than BD patients with suicidal ideation (<em>p</em>=0.036), and plasma T levels were associated with diagnosis (OR<sub>adjus</sub>=0.777, <em>p</em>=0.023). In adults, plasma ACTH levels were elevated in MDD versus BD (<em>p</em>=0.012) and were also diagnosis-related (OR<sub>adjus</sub>=0.972, <em>p</em>=0.019). Plasma levels of other hormones were not significantly different between MDD and BD in adolescents or adults (all <em>p</em>>0.05).</div></div><div><h3>Conclusions</h3><div>There was an age-specific difference in the T and ACTH between depressed patients with MDD and BD. Suicidal ideation was linked to T in adolescents.</div></div>\",\"PeriodicalId\":20836,\"journal\":{\"name\":\"Psychoneuroendocrinology\",\"volume\":\"172 \",\"pages\":\"Article 107227\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychoneuroendocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306453024002725\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychoneuroendocrinology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306453024002725","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
The differences in testosterone and stress hormones between unipolar and bipolar depression in adolescents and adults
Background
While patients with major depressive disorder (MDD) and bipolar disorder (BD) often exhibit aberrant hormones, it is still unknown whether the hormones differ between MDD and BD across the age spectrum. We aimed to investigate the differences in testosterone and stress hormones between depressed patients with MDD and BD in adolescents and adults, and the impact of suicidal ideation on these.
Methods
A total of 432 depressed patients (270 MDD and 162 BD) were recruited, including 177 adolescents and 255 adults. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol (CORT), testosterone (T), and prolactin (PRL) were measured in all patients. Suicidal ideation was assessed by item 3 of the Hamilton Depression Rating Scale.
Results
In adolescents, plasma T levels were higher in MDD than in BD (p=0.018), MDD patients with suicidal ideation exhibited higher T levels than BD patients with suicidal ideation (p=0.036), and plasma T levels were associated with diagnosis (ORadjus=0.777, p=0.023). In adults, plasma ACTH levels were elevated in MDD versus BD (p=0.012) and were also diagnosis-related (ORadjus=0.972, p=0.019). Plasma levels of other hormones were not significantly different between MDD and BD in adolescents or adults (all p>0.05).
Conclusions
There was an age-specific difference in the T and ACTH between depressed patients with MDD and BD. Suicidal ideation was linked to T in adolescents.
期刊介绍：
Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.
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