与莫亚莫亚氏病视力损伤和眼部疾病相关的风险因素和特征：来自全国数据库的启示

IF 2.6 3区医学 Q2 OPHTHALMOLOGY Ophthalmology and Therapy Pub Date : 2024-11-23 DOI:10.1007/s40123-024-01052-4

Youyi Song, Xin Yang, Hongzhu Yang, Hongyun Mei, Xuedan Lu, Hao Xie, Qinfeng Yang, Wenbin Duan

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引用次数: 0

摘要

简介本研究旨在调查一种罕见的脑血管疾病--莫亚莫亚氏病（moyamoya disease，MMD）患者视力损伤和眼部疾病的发病率和风险因素。了解这些关联对于改善患者管理和治疗效果至关重要：本研究利用《国际疾病分类》（ICD）第 9 版（ICD-9-CM）和第 10 版（ICD-10-CM）的代码来定义全国住院病人抽样数据库（NIS）中的诊断、并发症和手术。数据元素从出院摘要中提取。统计分析使用 IBM SPSS 统计软件第 25 版进行。单变量分析采用了卡方检验，以评估视力损伤、眼部疾病和多发性硬化症之间的关系。随后，利用多变量逻辑回归计算出 10 年间的几率比（OR）及其相应的 95% 置信区间（CI），以进一步研究这些关系：结果：麻风病患者视力损伤和眼部疾病的发病率为 3.7%。MMD患者的视力损伤和眼部疾病与亚洲或太平洋岛民种族（OR = 1.538，95% CI 1.058-2.237）、自费保险（OR = 1.796，95% CI 1.503-3.061）以及在中西部或中北部地区住院（OR = 1.466，95% CI 1.035-2.076）有关。moyamoya 病的视力损害和眼部疾病与缺血性中风（OR = 2.001，95% CI 1.564-2.560）、高血压（OR = 1.508，95% CI 1.089-2.088）、头痛（OR = 2.834，95% CI 1.968-4.081）、偏头痛（OR = 2.156，95% CI 1.544-3.011）、记忆力减退（OR = 3.866，95% CI 1.493-10.012）和头晕（OR = 1.322，95% CI 0.549-3.182）：我们对美国大量人口样本进行的分析表明，多发性硬化症与视力障碍和眼部疾病之间存在显著关联。

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Risk Factors and Characteristics Associated with Visual Impairment and Eye Diseases in Moyamoya Disease: Insights from a National Database.

Introduction: This study aims to investigate the incidence and risk factors of visual impairment and eye diseases in patients with moyamoya disease (MMD), a rare cerebrovascular disorder. Understanding these associations is crucial for improving patient management and outcomes.

Methods: This study utilized International Classification of Diseases (ICD) codes from both the 9th edition (ICD-9-CM) and 10th edition (ICD-10-CM) to define diagnoses, complications, and procedures within the National Inpatient Sample (NIS) Database. Data elements were extracted from discharge summaries. Statistical analysis was performed using IBM SPSS Statistics software version 25. Chi-square tests were employed for univariate analysis to assess the relationships between visual impairment, eye diseases, and MMD. Subsequently, multivariate logistic regression was utilized to calculate odds ratios (OR) and their corresponding 95% confidence intervals (CI) over a 10-year period to further investigate these relationships.

Results: The incidence of visual impairment and eye diseases in MMD was 3.7%. Visual impairment and eye diseases in MMD were associated with Asian or Pacific Islander race (OR = 1.538, 95% CI 1.058-2.237), self-pay insurance (OR = 1.796, 95% CI 1.503-3.061), and hospitalization in the Midwest or North Central region (OR = 1.466, 95% CI 1.035-2.076). Visual impairment and eye diseases in moyamoya disease were associated with ischemic stroke (OR = 2.001, 95% CI 1.564-2.560), hypertension (OR = 1.508, 95% CI 1.089-2.088), headache (OR = 2.834, 95% CI 1.968-4.081), migraine (OR = 2.156, 95% CI 1.544-3.011), memory loss (OR = 3.866, 95% CI 1.493-10.012), and dizziness (OR = 1.322, 95% CI 0.549-3.182).

Conclusions: Our analysis of a large, population-based sample in the US reveals a notable association between MMD and the presence of visual impairment and eye diseases.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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