评估 SORG 机器学习算法在预测腰椎手术患者出院处置方面的性能

Omar Salim , Mohamed S Draz , Emily R Bligh , Calan Mathieson
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引用次数: 0

摘要

目的腰椎手术后的延期入院人数不断增加,这通常是由于对需要非居家出院进行康复治疗的患者的识别效率低下造成的。哈佛大学医学院索尔格骨科研究小组开发了一种机器学习算法,用于预测腰椎手术后的出院情况。本研究在一个独立的三级中心患者队列中评估了该算法的预测性能。方法回顾性审查了英国一家三级神经外科中心在 2017 年 7 月至 2021 年期间进行的所有成人腰椎间盘变性或突出症择期手术的医疗记录。对术前变量进行了整理,并记录了出院目的地。使用一致性(c)统计量、布赖尔评分和校准图分析算法预测。计算了阳性和阴性预测值(PPV、NPV),并绘制了决策曲线分析图(DCA)。2.8%的患者接受了非居家出院治疗。大多数患者(98.4%)在1/2脊柱水平接受过手术,且功能独立(84.5%)。算法预测的 c 统计量为 0.88,布赖尔评分为 0.029。算法对数据的校准有误(校准图斜率为 1.31,截距为-1.12)。在非正常出院风险阈值为 0.25 时,PPV 为 0.19,NPV 为 0.98。DCA显示出的临床实用性有限。结论该队列的算法预测性能参差不齐,显示出较强的区分度,但校准较差,对非正常出院的估计过高。患者管理方法的差异和非家庭出院率较低可能是造成这种情况的原因。在临床应用之前,对不同的医疗系统进行更大规模的验证研究,同时开发特定地域的算法,将提高预测的准确性。
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Evaluating the performance of the SORG machine learning algorithm for predicting discharge disposition in lumbar surgery patients

Purpose

Protracted admissions following lumbar surgeries are rising, often stemming from inefficient identification of patients requiring nonhome discharge for rehabilitation. The SORG Orthopaedic Research Group at Harvard Medical School have developed a machine learning algorithm for predicting discharge following lumbar surgery. This study assessed its predictive performance on an independent tertiary centre patient cohort.

Methods

Medical records were retrospectively reviewed for all elective adult lumbar disc degeneration or herniation surgeries performed between July 2017–2021 at a tertiary neurosurgical centre in the United Kingdom. Preoperative variables were collated and discharge destinations noted. Algorithm predictions were analysed using the concordance (c) statistic, Brier score and calibration plot. Positive and negative predictive values (PPV, NPV) were calculated, and a decision curve analysis (DCA) plotted.

Results

251 subjects were included (48.2 % female, mean age 55.3 years). 2.8 % underwent nonhome discharge. Most had surgery at 1/2 spinal levels (98.4 %) and were functionally independent (84.5 %). Algorithm predictions yielded a 0.88 c-statistic and 0.029 Brier score. The algorithm was miscalibrated to the data (calibration plot slope 1.31 and intercept -1.12). At a 0.25 threshold for nonroutine discharge risk, the PPV was 0.19 and NPV 0.98. DCA revealed limited clinical utility.

Conclusions

Algorithm predictive performance was mixed for this cohort, displaying strong discrimination but poor calibration and overestimation of nonroutine discharges. Differences in patient management practices and the low nonhome discharge rate may explain this. Larger validation studies across different healthcare systems, alongside geographically specific algorithm development, will improve predictive accuracy prior to clinical application.
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来源期刊
Seminars in Spine Surgery
Seminars in Spine Surgery Medicine-Surgery
CiteScore
0.50
自引率
0.00%
发文量
53
审稿时长
2 days
期刊介绍: Seminars in Spine Surgery is a continuing source of current, clinical information for practicing surgeons. Under the direction of a specially selected guest editor, each issue addresses a single topic in the management and care of patients. Topics covered in each issue include basic anatomy, pathophysiology, clinical presentation, management options and follow-up of the condition under consideration. The journal also features "Spinescope," a special section providing summaries of articles from other journals that are of relevance to the understanding of ongoing research related to the treatment of spinal disorders.
期刊最新文献
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