德国筛查出和未筛查出结肠直肠癌的比例和特征。

IF 2.7 3区 医学 Q3 ONCOLOGY Acta Oncologica Pub Date : 2024-11-24 DOI:10.2340/1651-226X.2024.40234
Michel Hornschuch, Sarina Schwarz, Ulrike Haug
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引用次数: 0

摘要

背景:德国长期提供结直肠癌(CRC)筛查服务。我们旨在量化和描述德国筛查出的结直肠癌(sdCRC):我们基于覆盖约 20% 德国人口的医疗数据库开展了一项横断面研究;我们纳入了 2010-2018 年期间确诊的年龄≥ 55 岁的 CRC 患者。在确诊前 180 天内接受过结肠镜筛查或粪便潜血试验后接受结肠镜检查的患者被归类为 sdCRC,并与非 sdCRC 在年龄、分期和合并症方面进行了比较:2018年,25%的男性和22%的女性CRC患者通过筛查发现。就所有纳入的 CRC 病例(N = 82,538 例)的特征而言,sdCRC 患者比非 sdCRC 患者更年轻(男女平均差异:2.6 / 4.4 岁)。在晚期和非晚期 CRC 患者中,女性的比例分别为 33% 和 42%(男性分别为 36% 和 45%)。严重合并症在非晚期 CRC 中的发病率高于晚期 CRC(例如,在 65-74 岁的男性/女性患者中:35% 对 27% / 26% 对 19%)。两组患者的高血压和肥胖患病率相似:我们的研究表明,德国约有四分之一的 CRC 是通过筛查发现的。在非晚期结肠癌患者中,晚期和严重合并症比晚期结肠癌更常见。
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Proportion and characteristics of screen-detected and non-screen-detected colo-rectal cancers in Germany.

Background: Germany has a long-standing colorectal cancer (CRC) screening offer. We aimed to quantify and characterize screen-detected colorectal cancers (sdCRCs) in Germany.

Methods: We conducted a cross-sectional study based on a healthcare database covering ~20% of the German population; we included CRC patients aged ≥ 55 years diagnosed in 2010-2018. Patients with a screening colonoscopy or a fecal occult blood test followed by colonoscopy within 180 days before diagnosis were classified as sdCRCs and compared to non-sdCRCs regarding age, stage and comorbidities.

Results: In 2018, 25% of male and 22% of female CRC patients were screen-detected. Regarding characteristics of all included CRC cases (N = 82,538), sdCRC patients were younger than non-sdCRCs (average difference men / women: 2.6 / 4.4 years). The proportion of advanced CRC among sdCRCs and non-sdCRCs, respectively, was 33 and 42% in women (men: 36 and 45%). Severe comorbidities were more prevalent in non-sdCRCs compared to sdCRCs (e.g. in male / female patients aged 65-74: 35% vs. 27% / 26% vs. 19%). Prevalences of hypertension and obesity were similar in both groups.

Interpretation: Our study suggests that about one fourth of CRCs in Germany are screen-detected. Among patients with non-sdCRC, not only advanced stage but also severe comorbidity was more common than in sdCRCs.

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来源期刊
Acta Oncologica
Acta Oncologica 医学-肿瘤学
CiteScore
4.30
自引率
3.20%
发文量
301
审稿时长
3 months
期刊介绍: Acta Oncologica is a journal for the clinical oncologist and accepts articles within all fields of clinical cancer research. Articles on tumour pathology, experimental oncology, radiobiology, cancer epidemiology and medical radio physics are also welcome, especially if they have a clinical aim or interest. Scientific articles on cancer nursing and psychological or social aspects of cancer are also welcomed. Extensive material may be published as Supplements, for which special conditions apply.
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