Mehrdad Hashemi, Saloomeh Khoushab, Mina Hobabi Aghmiuni, Saeid Nemati Anaraki, Mina Alimohammadi, Afshin Taheriazam, Najma Farahani, Maliheh Entezari
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引用次数: 0
摘要
在全球范围内，口腔癌（OC）是一个重大的公共卫生问题，每年都会导致大量患者死亡。早期发现和治疗对改善患者预后至关重要。最近在 DNA 测序和转录组分析方面取得的进展揭示了广泛的非编码 RNA（ncRNA）转录，凸显了其调控的重要性。NcRNAs 影响基因组转录和翻译以及分子信号通路，因此在各种临床应用中具有重要价值。将空间转录组学（ST）和空间代谢组学（SM）与单细胞RNA测序相结合，可以更深入地了解肿瘤微环境，提高OC的诊断和治疗精度。此外，唾液生物标记物的探索提供了一种非侵入性诊断途径。本文探讨了 ncRNA 作为 OC 诊断和治疗工具的潜力。
Non-coding RNAs in oral cancer: Emerging biomarkers and therapeutic frontier.
Around the world, oral cancer (OC) is a major public health problem, resulting in a significant number of deaths each year. Early detection and treatment are crucial for improving patient outcomes. Recent progress in DNA sequencing and transcriptome profiling has revealed extensive non-coding RNAs (ncRNAs) transcription, underscoring their regulatory importance. NcRNAs influence genomic transcription and translation and molecular signaling pathways, making them valuable for various clinical applications. Combining spatial transcriptomics (ST) and spatial metabolomics (SM) with single-cell RNA sequencing provides deeper insights into tumor microenvironments, enhancing diagnostic and therapeutic precision for OC. Additionally, the exploration of salivary biomarkers offers a non-invasive diagnostic avenue. This article explores the potential of ncRNAs as diagnostic and therapeutic tools for OC.
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Heliyon is an all-science, open access journal that is part of the Cell Press family. Any paper reporting scientifically accurate and valuable research, which adheres to accepted ethical and scientific publishing standards, will be considered for publication. Our growing team of dedicated section editors, along with our in-house team, handle your paper and manage the publication process end-to-end, giving your research the editorial support it deserves.
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