Ketogenic Diet Improves Sleep Quality and Daytime Sleepiness in Chronic Migraine: A Pilot Study.

Aims: The aim of this study is to assess the sleep quality and daytime sleepiness improvement in chronic migraineurs after 6 months of a 2:1 KD (ketogenic diet) and LGID (low-glycemic-index diet).

Methods: Twenty-six patients underwent 2:1 KD (11 patients) and LGID (15 patients). PSQI (Pittsburgh sleep quality index) and ESS (Epworth sleepiness scale) were administered at the baseline and the 3-month and 6-month follow-up. MIDAS (Migraine Disability Assessment), HIT-6 (Headache Impact Test 6), migraine frequency (migraine days per month), migraine intensity, BMI (Body Mass Index), FM (Fat Mass), and FFM (Fat-Free Mass) were also assessed.

Results: PSQI (F_{1.544, 38.606} = 7.250; p = 0.004), ESS (F_{1.988, 49.708} = 9.938; p < 0.001), HIT-6 (F_{1.432, 35.805} = 12.693; p < 0.001), migraine frequency (F_{1.522, 38.041} = 23.070; p < 0.001), migraine intensity (F_{1.949, 48.721} = 18.798; p < 0.001), BMI (F_{1.274, 31.857} = 38.191; p < 0.001), and FM (F_{1.245, 31.134} = 45.487; p < 0.001) improved significantly. The MIDAS (F_{1.005, 25.121} = 3.037; p = 0.093) and the FMM (F_{1.311, 32.784} = 1.741; p = 0.197) did not improve significantly. The ESS (p = 0.712) and PSQI (p = 0.776) data at 3-month and 6-month follow-ups did not differ significantly, as well as for migraine frequency, migraine intensity, BMI, FM, and HIT-6. A mild correlation emerged between the mean FM and mean ESS reduction during the 6 months (r = 0.497, p = 0.010).

Conclusions: Six months of LGID and 2:1 KD can improve sleep quality and daytime sleepiness in patients with chronic migraine. The effectiveness on migraine, sleep quality, and daytime sleepiness does not differ significantly between the 3-month and 6-month follow-up periods.