M K Gulov, K R Ruziboyzoda, E Sh Nosirov, S G Ali-Zade, B I Safarov
{"title":"[急性胰腺炎中的氧化毒血症、缺氧和腹内高压]。","authors":"M K Gulov, K R Ruziboyzoda, E Sh Nosirov, S G Ali-Zade, B I Safarov","doi":"10.17116/hirurgia202411138","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the changes in indicators of oxidative toxemia, hypoxia and intra-abdominal hypertension in various forms of acute pancreatitis.</p><p><strong>Material and methods: </strong>The results of complex diagnostics in 62 patients with various forms of acute pancreatitis were analyzed. We estimated the indicators of oxidative status, hypoxia and intra-abdominal hypertension. Edematous pancreatitis was diagnosed in 35 (56.5%) patients, destructive acute pancreatitis - in 27 (43.5%) patients (sterile pancreatic necrosis in 14 (22.6%) patients, and infected pancreatic necrosis in 13 (20.9%) patients).</p><p><strong>Results: </strong>Progression of disease is followed by active lipid peroxidation with accumulation of conjugated dienes and malondialdehyde, as well as increase in serum lactate and pyruvate levels. Intra-abdominal pressure increases with progression of disease and destructive processes. There was direct correlation between intra-abdominal pressure and clinical form of acute pancreatitis (<i>r</i>=0.8033, <i>p</i><0.001). The same was true for intra-abdominal pressure and indicators of oxidative toxemia (conjugated dienes - <i>p</i><0.001, malondialdehyde - <i>p</i><0.001) and hypoxia (lactate - <i>p</i><0.001, pyruvate - <i>p</i><0.001, and hypoxia coefficient - <i>p</i><0.001).</p><p><strong>Conclusion: </strong>A comprehensive examination of patients with acute pancreatitis allows to analyze lipid peroxidation, hypoxia and intra-abdominal hypertension. These parameters depend on clinical form of disease.</p>","PeriodicalId":35986,"journal":{"name":"Khirurgiya","volume":" 11","pages":"38-45"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Oxidative toxemia, hypoxia and intra-abdominal hypertension in acute pancreatitis].\",\"authors\":\"M K Gulov, K R Ruziboyzoda, E Sh Nosirov, S G Ali-Zade, B I Safarov\",\"doi\":\"10.17116/hirurgia202411138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the changes in indicators of oxidative toxemia, hypoxia and intra-abdominal hypertension in various forms of acute pancreatitis.</p><p><strong>Material and methods: </strong>The results of complex diagnostics in 62 patients with various forms of acute pancreatitis were analyzed. We estimated the indicators of oxidative status, hypoxia and intra-abdominal hypertension. Edematous pancreatitis was diagnosed in 35 (56.5%) patients, destructive acute pancreatitis - in 27 (43.5%) patients (sterile pancreatic necrosis in 14 (22.6%) patients, and infected pancreatic necrosis in 13 (20.9%) patients).</p><p><strong>Results: </strong>Progression of disease is followed by active lipid peroxidation with accumulation of conjugated dienes and malondialdehyde, as well as increase in serum lactate and pyruvate levels. Intra-abdominal pressure increases with progression of disease and destructive processes. There was direct correlation between intra-abdominal pressure and clinical form of acute pancreatitis (<i>r</i>=0.8033, <i>p</i><0.001). The same was true for intra-abdominal pressure and indicators of oxidative toxemia (conjugated dienes - <i>p</i><0.001, malondialdehyde - <i>p</i><0.001) and hypoxia (lactate - <i>p</i><0.001, pyruvate - <i>p</i><0.001, and hypoxia coefficient - <i>p</i><0.001).</p><p><strong>Conclusion: </strong>A comprehensive examination of patients with acute pancreatitis allows to analyze lipid peroxidation, hypoxia and intra-abdominal hypertension. These parameters depend on clinical form of disease.</p>\",\"PeriodicalId\":35986,\"journal\":{\"name\":\"Khirurgiya\",\"volume\":\" 11\",\"pages\":\"38-45\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Khirurgiya\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17116/hirurgia202411138\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Khirurgiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/hirurgia202411138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[Oxidative toxemia, hypoxia and intra-abdominal hypertension in acute pancreatitis].
Objective: To study the changes in indicators of oxidative toxemia, hypoxia and intra-abdominal hypertension in various forms of acute pancreatitis.
Material and methods: The results of complex diagnostics in 62 patients with various forms of acute pancreatitis were analyzed. We estimated the indicators of oxidative status, hypoxia and intra-abdominal hypertension. Edematous pancreatitis was diagnosed in 35 (56.5%) patients, destructive acute pancreatitis - in 27 (43.5%) patients (sterile pancreatic necrosis in 14 (22.6%) patients, and infected pancreatic necrosis in 13 (20.9%) patients).
Results: Progression of disease is followed by active lipid peroxidation with accumulation of conjugated dienes and malondialdehyde, as well as increase in serum lactate and pyruvate levels. Intra-abdominal pressure increases with progression of disease and destructive processes. There was direct correlation between intra-abdominal pressure and clinical form of acute pancreatitis (r=0.8033, p<0.001). The same was true for intra-abdominal pressure and indicators of oxidative toxemia (conjugated dienes - p<0.001, malondialdehyde - p<0.001) and hypoxia (lactate - p<0.001, pyruvate - p<0.001, and hypoxia coefficient - p<0.001).
Conclusion: A comprehensive examination of patients with acute pancreatitis allows to analyze lipid peroxidation, hypoxia and intra-abdominal hypertension. These parameters depend on clinical form of disease.