从工作台到床边:细胞外囊泡在软骨损伤治疗中的作用。

IF 8.1 Q1 ENGINEERING, BIOMEDICAL Biomaterials research Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI:10.34133/bmr.0110
Pan Jin, Huan Liu, Xichi Chen, Wei Liu, Tongmeng Jiang
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引用次数: 0

摘要

软骨修复是治疗关节损伤的关键。然而,由于软骨缺乏血管和神经,其自我修复能力极低。细胞外囊泡(EVs)是一种双层纳米囊泡,其膜主要由神经酰胺、胆固醇、磷酸甘油和长链游离脂肪酸组成,内含 DNA、RNA 和蛋白质(如整合素和酶)。多项研究表明,通过介导细胞间通信和调节机制,EVs 是修复软骨的有效治疗方案。本综述总结了EVs在软骨修复中的不同来源(哺乳动物、植物和细菌)和用途、损伤软骨细胞捕获EVs的机制以及EVs的定量和储存等方面的最新发现,可为促进EVs在软骨损伤治疗领域的发展提供科学指导。
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From Bench to Bedside: The Role of Extracellular Vesicles in Cartilage Injury Treatment.

Cartilage repair is the key to the treatment of joint-related injury. However, because cartilage lacks vessels and nerves, its self-repair ability is extremely low. Extracellular vesicles (EVs) are bilayer nanovesicles with membranes mainly composed of ceramides, cholesterol, phosphoglycerides, and long-chain free fatty acids, containing DNA, RNA, and proteins (such as integrins and enzymes). For mediating intercellular communication and regulating mechanisms, EVs have been shown by multiple studies to be effective treatment options for cartilage repair. This review summarizes recent findings of different sources (mammals, plants, and bacteria) and uses of EVs in cartilage repair, mechanisms of EVs captured by injured chondrocytes, and quantification and storage of EVs, which may provide scientific guidance for promoting the development of EVs in the field of cartilage injury treatment.

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