[Vitamin D Deficiency In Advanced Breast Cancer Risk In Mali].

Aims: The aim of this study was to determine the association between vitamin D deficiency and advanced BC in a Malian women population.

Methods: This is a prospective cross-sectional study, conducted during 4 months, from August 2021 to November 2021. The assays were performed on immunodiagnostic and biochemistry devices in Rodolphe Merieux Laboratory.

Results: We included 77 women diagnosed with advanced breast cancer. The mean age of the study population was 48.51 ± 13.02 years. The mean plasma concentrations of 25(OH)D were 20.65 ± 6.76 ng/ml and 18.89 ± 6.12 ng/ml (p=0.274) in groups III and IV, respectively. Stage III was predominant, comprising 67.5% of the cases, and there were no significant differences between stages III and IV regarding phospho-calcium biological markers. Our results showed a greater deficiency in vitamin D at stage III compared to stage IV, with p=0.782. The logistic regression model demonstrated a significant decrease in the relative risk of advanced breast cancer across the quartiles of vitamin D (p=0.039). There was no association with serum calcium, phosphate, plasma creatinine, and glomerular filtration rate (GFR) (p>0.05).

Conclusions: Our findings show an decrease of the risk of breast cancer about vitamin D levels in our population. These results suggest an association between vitamin D and the risk of advanced breast cancer. Further studies are needed to determine the mechanism of vitamin D deficiency in advanced breast cancer.