Transamidation of primary thioamides with primary and secondary amines via C(S)–N bond cleavage and formation by hydroxylamine hydrochloride catalysis†

Hydroxylamine hydrochloride-catalyzed transamidation of primary thioamides with primary and secondary amines via C(S)–N bond cleavage and formation has been reported. Readily available primary thioamides are employed as substrates to convert desired secondary and tertiary thioamides using green and benign hydroxylamine hydrochloride as a catalyst. The utility of this approach has been demonstrated via excellent functional group tolerance and broad substrate scope, which is expected to be widely used in fields such as synthetic chemistry, pharmaceutical chemistry, etc.