术中经食道超声心动图评估的肾阻力指数与心脏手术后急性肾损伤有关:一项前瞻性观察研究。

IF 2.9 3区 医学 Q1 ANESTHESIOLOGY Minerva anestesiologica Pub Date : 2024-11-26 DOI:10.23736/S0375-9393.24.18464-7
Richa Dhawan, Kristin Trela, Joshua M Junge, Daniel Viox, Kristen E Wroblewski, Mark A Chaney
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引用次数: 0

摘要

背景:急性肾损伤(AKI)是心脏手术后的主要健康负担。肾血管收缩和静脉充血可通过经食道超声心动图(TEE)进行评估。主要目的是确定通过 TEE 测量术中肾脏阻力指数 (RRI) 和门静脉搏动分数 (PF) 的可行性。次要目标是确定 RRI 和/或 PF 与术后 AKI、重症监护室(ICU)住院时间、住院时间和 30 天死亡率之间的关系:这是一项前瞻性观察研究,在一所大学的单一中心进行,对象是接受择期心脏手术的成年患者。在 CPB 之前、CPB 之后和关胸之后进行术中 RRI 和 PF 测量:结果:80 名患者符合资格标准并同意接受治疗。总体可行率为 91%(73/80),RRI 测量率为 96%(77/80),PF 测量率为 94%(75/80)。对 69 名患者进行了进一步分析。CPB 前 RRI 与 AKI 显著相关([OR][95%CI] 2.15 [1.07-4.33],P=0.03),AUC 为 0.68([95%CI] 0.55-0.81,P=0.02)。胸腔关闭后 RRI>0.75 与 AKI 显著相关([OR][95%CI] 3.54 [1.18-10.62],P=0.02)。三个时间点的组合与 AKI 有明显相关性([AUC][95% CI] 0.71 [0.58-0.84],P=0.007)。PF与AKI无明显相关性:本研究表明,术中 TEE 测量 RRI 和 PF 的可行性很高,术后 AKI 与 CPB 前 RRI、关胸后 RRI 以及三个时间点的 RRI 组合之间存在显著相关性。
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Renal resistive index assessment by intraoperative transesophageal echocardiography is associated with acute kidney injury after cardiac surgery: a prospective observational study.

Background: Acute kidney injury (AKI) is a major health burden after cardiac surgery. Renal vasoconstriction and venous congestion can be assessed via transesophageal echocardiography (TEE). The primary objective is to determine feasibility of measuring intraoperative Renal resistive index (RRI) and portal vein pulsatility fraction (PF) by TEE. The secondary objectives are to determine the association between RRI and/or PF and postoperative AKI, Intensive Care Unit (ICU) length of stay, hospital length of stay, and 30-day mortality.

Methods: This is a prospective observational study at a single center University setting in adult patients undergoing elective cardiac surgery. Intraoperative RRI and PF measurements were obtained prior to CPB, after CPB, and after chest closure.

Results: Eighty patients met eligibility criteria and consented. Overall feasibility rate was 91% (73/80), RRI measured in 96% (77/80) and PF measured in 94% (75/80). Further analyses was conducted in 69 patients. RRI prior to CPB significantly correlated with AKI ([OR][95% CI] 2.15 [1.07-4.33], P=0.03) with an AUC of 0.68 ([95%CI] 0.55-0.81, P=0.02). Post-chest closure RRI>0.75 significantly correlated with AKI ([OR][95% CI] 3.54 [1.18-10.62], P=0.02). Combination of the three timepoints significantly associated with AKI ([AUC][95% CI] 0.71 [0.58-0.84], P=0.007). PF did not significantly correlate with AKI.

Conclusions: This study demonstrates high feasibility for obtaining intraoperative TEE measurement of RRI and PF and significant correlation between postoperative AKI with pre CPB RRI, post chest closure RRI, and the combination of RRI at the three timepoints.

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来源期刊
Minerva anestesiologica
Minerva anestesiologica 医学-麻醉学
CiteScore
4.50
自引率
21.90%
发文量
367
审稿时长
4-8 weeks
期刊介绍: Minerva Anestesiologica is the journal of the Italian National Society of Anaesthesia, Analgesia, Resuscitation, and Intensive Care. Minerva Anestesiologica publishes scientific papers on Anesthesiology, Intensive care, Analgesia, Perioperative Medicine and related fields. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors.
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