在冷冻胚胎移植周期中反复移植失败患者的第 5 天和第 6 天连续移植囊胚。

IF 2.6 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Reproductive Sciences Pub Date : 2024-11-25 DOI:10.1007/s43032-024-01734-1
Qi Jin, Xiaohua Jiang, Lu Zong, Tong Wu, Shengxia Zheng, Limin Wu, Bo Xu
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引用次数: 0

摘要

本研究旨在评估哪种冷冻胚胎移植(FET)策略对复发性着床失败(RIF)人群有益。2020 年 7 月至 2023 年 10 月期间,对 336 名 RIF 妇女进行了回顾性研究。根据FET方案,患者被分为三组。三种 FET 方案包括在第 5 天和第 6 天移植一个囊胚(第 1 组,n = 138);在第 3 天移植一个分裂期胚胎,在第 5 天移植一个囊胚(第 2 组,n = 55);在第 5 天移植双囊胚(第 3 组,n = 143)。与传统的第 5 天双囊胚移植策略和第 3 天移植一个卵裂期胚胎、第 5 天移植一个囊胚的策略相比,第 5 天和第 6 天连续囊胚 ET 策略显著提高了 RIF 患者的体外受精成功率。与第 5 天双囊胚移植相比,临床妊娠率和植入率均有所提高(51.75% 对 64.49%,P<0.05)。
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Sequential Transfer of Blastocysts on Day 5 and Day 6 in Patients with Repeated Implantation Failure in Frozen Embryo Transfer Cycle.

The aim of this study was to evaluate which frozen embryo transfer (FET) strategy benefits the recurrent implantation failure (RIF) population. A retrospective study of 336 women with RIF was performed from July 2020 to October 2023. The patients were divided into three groups according to the FET protocol. The three FET protocols included transferring a blastocyst on both days 5 and 6 (Group 1, n = 138); transferring a cleavage-stage embryo on day 3 and a blastocyst on day 5 (Group 2, n = 55); and transferring double blastocysts on day 5 (Group 3, n = 143).The sequential day 5 and day 6 blastocyst ET strategy significantly improved in vitro fertilization success rates compared with those of both the traditional double-blastocyst day 5 transfer strategy and the strategy involving one cleavage-stage embryo transfer on day 3 and one blastocyst transfer on day 5 in RIF patients. Compared with those observed in Day 5 double-blastocyst transfer, the rates of clinical pregnancy and implantation increased (51.75% vs. 64.49%, P < 0.001 and 37.06% vs. 41.3%, P = 0.005, respectively), while the rates of biochemical pregnancy and multiple gestation decreased (18.18% vs. 12.32%, P = 0.006 and 43.24% vs. 28.09%, P = 0.044, respectively) with the new protocol.Blastocysts from sequential embryo transfer on day 5 and day 6 were more effective than those from the traditional FET protocol at improving pregnancy outcomes and lowering the multiple pregnancy rate in RIF patients. When only one or zero good-quality blastocysts are available, sequential blastocyst ET on days 5 and 6 should be considered.

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来源期刊
Reproductive Sciences
Reproductive Sciences 医学-妇产科学
CiteScore
5.50
自引率
3.40%
发文量
322
审稿时长
4-8 weeks
期刊介绍: Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
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