Josiane L. Broussard, Amanda Garfield, Simona Zarini, Joseph T. Brozinick, Leigh Perreault, Sean A. Newsom, Darcy Kahn, Anna Kerege, Karin Zemski Berry, Hai Hoang Bui, Bryan C. Bergman
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引用次数: 0
摘要
目的：循环血脂与胰岛素抵抗和心血管疾病风险增加有关。我们以前曾报道过，胰岛素抵抗的人体内二氢甘油三酯（一种特殊的鞘脂类）会升高；然而，对于胰岛素敏感的生活方式干预是否能改善鞘脂类和其他脂类的特征，我们所知甚少：方法： 共有 21 名肥胖症患者参加了为期 3 个月的生活方式干预，其中包括减肥和运动训练。通过高胰岛素血糖钳夹评估胰岛素敏感性，并进行血清脂质组学研究：结果：干预后，体重指数明显降低了 10%；VO2 峰值和胰岛素敏感性分别提高了 12% 和 57%；血清总三酰甘油 (TAG)、二酰甘油、二氢甘油酰胺、鞘氨醇-1-磷酸酯和鞘氨醇-1-磷酸酯以及特定种类的二氢甘油酰胺（C18:0 和 C24:1）均明显减少。干预前 TAG 浓度较高的人血清脂质明显减少，而干预前 TAG 浓度较低的人血清脂质没有明显变化：这些数据表明，以前与人类胰岛素抵抗有关的血清鞘脂种类可以通过胰岛素敏感的生活方式干预来减少。此外，由于与胰岛素抵抗有关的血清脂类会进一步减少，血清 TAG 升高的人可能会从提高胰岛素敏感性的生活方式干预中明显受益。
Combined diet and exercise training decreases serum lipids associated with insulin resistance
Objective
Circulating lipids are linked with insulin resistance and increased cardiovascular disease risk. We previously reported that dihydroceramides, a specific type of sphingolipid, are elevated in insulin-resistant individuals; however, little is known regarding whether insulin-sensitizing lifestyle interventions can improve profiles of sphingolipids and other lipid species.
Methods
A total of 21 individuals with obesity participated in a 3-month lifestyle intervention of combined weight loss and exercise training. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamps, and serum lipidomics was conducted.
Results
Following the intervention, BMI was significantly reduced by 10%; VO2peak and insulin sensitivity increased by 12% and 57%, respectively; and total serum triacylglycerol (TAG), diacylglycerol, dihydroceramides, sphingosine-1-phosphate, and sphinganine-1-phosphate were significantly reduced, as were specific species of dihydroceramides (C18:0 and C24:1). Individuals with higher preintervention TAG concentrations had significant decreases in serum lipids, which were not significantly changed in individuals with lower preintervention TAG.
Conclusions
These data show that serum sphingolipid species previously linked to insulin resistance in humans can be reduced with insulin-sensitizing lifestyle interventions. Furthermore, individuals with elevated serum TAG may significantly benefit from lifestyle interventions that increase insulin sensitivity due to a greater decrease in serum lipids related to insulin resistance.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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