乳酸杆菌 BIOTECH 1766 可减轻 ICR 小鼠铝中毒后的氧化应激和组织病理学变化。

Q4 Medicine Acta Medica Philippina Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.47895/amp.vi0.8005
Gerwin Louis T Dela Torre, Richelle Ann M Manalo, Szarina Krisha K Ko, Erna C Arollado, Arlene A Samaniego
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引用次数: 0

摘要

研究目的本研究旨在探讨乳酸杆菌 BIOTECH 1766 对 ICR 小鼠因铝(Al)中毒引起的大脑、肝脏和肾脏氧化损伤的保护作用:将 20 只小鼠分为四组(n = 5):(方法:将 20 只小鼠分为四组(n = 5):(I) 对照组,(II) Al 组,(III) 柠檬酸(CA)组,(IV) L. brevis BIOTECH 1766 组。治疗期为 14 天,其中 I 组和 II 组接受无菌水,III 组和 IV 组分别接受 10 mg/kg 体重的 CA 和 1 x 109 cfu/kg 体重的 L. brevis BIOTECH 1766。第 15 天,除对照组外,其余各组均口服单次剂量为 1438 毫克/千克体重的 AlCl3 .6H2O。24 小时后,小鼠被安乐死,收集大脑、肝脏和肾脏,进行氧化应激标记物分析和组织病理学检查:结果:急性铝中毒导致组织中丙二醛(MDA)显著增加,组织中还原型谷胱甘肽(GSH)、过氧化氢酶(CAT)和超氧化物歧化酶(SOD)显著减少。用 CA 或 L. brevis BIOTECH 1766 预处理的小鼠肝脏中的 CAT 活性和所有三个器官中的 SOD 活性都明显降低。CA 和 L. brevis BIOTECH 1766 的预处理还能防止大面积器官损伤,后者能更好地防止肝脏损伤:结论:研究结果表明,L. brevis BIOTECH 1766 可改善小鼠大脑、肝脏和肾脏的氧化损伤,从而对急性铝中毒起到保护作用。
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Lactobacillus brevis BIOTECH 1766 Attenuates Oxidative Stress and Histopathological Changes following Aluminum Poisoning in ICR Mice.

Objective: The aim of this study was to investigate the protective effects of Lactobacillus brevis BIOTECH 1766 against oxidative damage in the brain, liver, and kidneys induced by aluminum (Al) poisoning in ICR mice.

Methods: Twenty mice were divided into four groups (n = 5): (I) control, (II) Al, (III) citric acid (CA), and (IV) L. brevis BIOTECH 1766 group. A 14-day treatment period was implemented, wherein groups I and II received sterile water, while groups III and IV received 10 mg/kg bw of CA and 1 x 109 cfu/kg bw of L. brevis BIOTECH 1766, respectively. On day 15, all except the control group received a single oral dose of 1438 mg/kg bw of AlCl3 .6H2O. After 24 h, mice were euthanized to collect the brain, liver, and kidneys for the oxidative stress marker analyses and histopathological examination.

Results: Acute intoxication of Al led to a significant increase in tissue malondialdehyde (MDA) and a significant decrease in the tissue's reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). Mice pretreated with CA or L. brevis BIOTECH 1766 have markedly reduced CAT activity in the liver, and SOD in all three organs. Extensive organ injuries were also prevented by CA and L. brevis BIOTECH 1766 pretreatment, with the latter providing better protection against liver damage.

Conclusion: The findings showed that L. brevis BIOTECH 1766 provides a protective effect against acute Al poisoning in mice by ameliorating oxidative damage in the brain, liver, and kidneys.

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Acta Medica Philippina
Acta Medica Philippina Medicine-Medicine (all)
CiteScore
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199
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