脊椎动物神经肌肉接头处的巨型微型终板电位：综述。

IF 2.7 4区医学 Q3 NEUROSCIENCES European Journal of Neuroscience Pub Date : 2024-11-26 DOI:10.1111/ejn.16624

Karim A Alkadhi

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引用次数: 0

摘要

脊椎动物的神经肌肉接头处会以低频率自然产生异常大振幅的自发微型终板电位（gMEPPs）。与正常的微型终板电位（nMEPPs）不同，这些 gMEPPs 持续时间长，达到峰值的时间也长。更引人注目的是，gMEPPs 似乎不受细胞外和细胞内 Ca+2 的影响，对温度的敏感性也高于 nMEPPs。河豚毒素会增强 gMEPPs，但乙酰胆碱（ACh）受体阻断剂会抑制 gMEPPs，这表明 ACh 是导致 gMEPPs 的神经递质。在肌肉因各种药物、毒素或疾病而变弱的情况下，gMEPPs 的频率会大大增加，这表明 gMEPPs 可能是神经营养机制的一部分，当正常功能受到损害时，它可以保持有效的神经肌肉传递。

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Giant miniature endplate potentials at vertebrate neuromuscular junctions: A review.

An unusually large amplitude spontaneous miniature endplate potentials (gMEPPs) occur naturally at low frequency at the vertebrate neuromuscular junction. Unlike the normal miniature endplate potentials (nMEPPs), these gMEPPs have long duration and long time to peak. More strikingly, gMEPPs seem to be independent of extracellular and intracellular Ca^+2. and have a greater temperature sensitivity than nMEPPs. They are potentiated by tetrodotoxin but inhibited by acetylcholine (ACh) receptor blockers indicating ACh is the neurotransmitter responsible for gMEPPs. The frequency of gMEPPs is greatly increased in muscles weakened by various drugs, toxins or disease conditions suggesting that gMEPPs may be a part of possible neurotrophic mechanism to preserve effective neuromuscular transmission when the normal function is compromised.

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来源期刊

European Journal of Neuroscience 医学-神经科学

CiteScore

7.10

自引率

5.90%

发文量

305

审稿时长

3.5 months

期刊介绍： EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.