一种新型石墨烯基纳米材料,用于开发治疗骨盆器官脱垂的骨盆植入物。

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-11-20 DOI:10.3390/jfb15110351
Amelia Seifalian, Alex Digesu, Vik Khullar
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引用次数: 0

摘要

石墨烯是 21 世纪的神奇材料,有望在材料科学领域取得尖端进展,并在各行各业得到广泛应用。本研究调查了石墨烯基纳米材料(GBNs)(商品名为 Hastalex®)在治疗盆腔器官脱垂(POP)手术植入物中的新型材料应用。本研究调查了该材料的机械性能和理化特性,主要关注其解决现有聚丙烯(PP)植入物局限性的潜力,聚丙烯植入物与多种并发症有关,已被多个国家禁止使用。衰减全反射傅立叶变换红外光谱(ATR-FTIR)证实了功能化氧化石墨烯(FGO)与基础聚合物链之间的结合。Hastalex 具有优异的机械性能,断裂时最大拉伸强度为 58 N/mm2,断裂伸长率为 701%,同时还能保持形状,不会产生塑性变形。这些结果与绵羊骨盆肌肉组织的结果相当。接触角测量结果表明,Hastalex 具有亲水性。扫描电子显微镜(SEM)和原子力显微镜(AFM)显示,Hastalex 具有均匀的表面纳米层状结构,可促进细胞与材料之间的相互作用。这些结果证实了 Hastalex 适用于开发治疗宫颈息肉的新型盆腔膜。
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A Novel Graphene-Based Nanomaterial for the Development of a Pelvic Implant to Treat Pelvic Organ Prolapse.

Graphene is the wonder material of the 21st century, promising cutting-edge advancements in material science with significant applications across all industries. This study investigates the use of a graphene-based nanomaterials (GBNs) ans trade-registered Hastalex®, as novel materials for surgical implants aimed at treating pelvic organ prolapse (POP). This study investigates the mechanical properties and physicochemical characteristics of the material, mainly focusing on its potential to address the limitations of existing polypropylene (PP) implants, which has been associated with numerous complications and banned across multiple countries. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) confirmed the bonding between functionalised graphene oxide (FGO) and the base polymer chain. Hastalex exhibited excellent mechanical properties with 58 N/mm2 maximum tensile strength at break and 701% elongation at break, whilst maintaining its shape with no plastic deformation. These results were comparable to that of sheep pelvic muscular tissue. Hastalex demonstrated its hydrophilic properties from contact angle measurements. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) showed a uniform plane with surface nanotopography, promoting cell-to-material interaction. The results confirmed the suitability of Hastalex in the development of a new pelvic membrane to treat POP.

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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
期刊最新文献
Strontium- and Copper-Doped Ceramic Granules in Bone Regeneration-Associated Cellular Processes. A Novel Graphene-Based Nanomaterial for the Development of a Pelvic Implant to Treat Pelvic Organ Prolapse. Spherical Shell Bioprinting to Produce Uniform Spheroids with Controlled Sizes. Correction: Jin et al. A pH-Responsive DNA Tetrahedron/Methotrexate Drug Delivery System Used for Rheumatoid Arthritis Treatment. J. Funct. Biomater. 2023, 14, 541. Properties, Production, and Recycling of Regenerated Cellulose Fibers: Special Medical Applications.
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