{"title":"老化扩大的核小体为细胞的死亡打开了大门。","authors":"","doi":"10.1038/s43587-024-00779-w","DOIUrl":null,"url":null,"abstract":"Nucleolar enlargement during aging alters the biophysical properties of nucleoli, which allows entry of DNA repair machinery that is normally excluded. In budding yeast this event triggers catastrophic global genome instability due to aberrant ribosomal DNA recombination, and imminently ends the yeast’s mitotic lifespan.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1678-1679"},"PeriodicalIF":17.0000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Old enlarged nucleoli open the door to the cell’s demise\",\"authors\":\"\",\"doi\":\"10.1038/s43587-024-00779-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nucleolar enlargement during aging alters the biophysical properties of nucleoli, which allows entry of DNA repair machinery that is normally excluded. In budding yeast this event triggers catastrophic global genome instability due to aberrant ribosomal DNA recombination, and imminently ends the yeast’s mitotic lifespan.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"4 12\",\"pages\":\"1678-1679\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00779-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00779-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Old enlarged nucleoli open the door to the cell’s demise
Nucleolar enlargement during aging alters the biophysical properties of nucleoli, which allows entry of DNA repair machinery that is normally excluded. In budding yeast this event triggers catastrophic global genome instability due to aberrant ribosomal DNA recombination, and imminently ends the yeast’s mitotic lifespan.
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