明显升高的 IgG 指数：区分神经梅毒和自身免疫性边缘脑炎的关键所在

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Internal Medicine Pub Date : 2024-11-28 DOI:10.2169/internalmedicine.4625-24

Yui Sanpei, Akira Hanazono, Momoka Funasaka, Keita Yasuda, Yoshiko Takahashi, Masashiro Sugawara

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引用次数: 0

摘要

我们在此报告了一名48岁的男性神经梅毒患者，其表现为边缘脑炎，起初被怀疑为自身免疫性边缘脑炎。患者表现出快速的行为变化，磁共振成像显示两个颞叶内侧均有高强度病变。诊断依据是症状、脑脊液异常和梅毒血清检测阳性。值得注意的是，脑脊液免疫球蛋白 G 指数明显升高（4.91）。该病例凸显了神经梅毒与自身免疫性肢端脑炎之间的诊断难题，因为其表现越来越不典型。在这类病例中，免疫球蛋白G指数明显升高可作为神经梅毒的重要诊断指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Markedly Elevated IgG Index: A Key to Differentiating Neurosyphilis from Autoimmune Limbic Encephalitis.

We herein report a 48-year-old man with neurosyphilis manifesting as limbic encephalitis, initially suspected to be autoimmune limbic encephalitis. The patient exhibited rapid behavioral changes, and magnetic resonance imaging showed high-intensity lesions in both medial temporal lobes. The diagnosis was based on symptoms, cerebrospinal fluid abnormalities, and positive serum tests for syphilis. Notably, the cerebrospinal fluid immunoglobulin G index was markedly elevated (4.91). This case highlights the diagnostic challenges in differentiating neurosyphilis from autoimmune limbic encephalitis, given the increasing atypical presentation. A markedly elevated immunoglobulin G index may serve as a valuable diagnostic indicator for neurosyphilis in such cases.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.