迷幻药对阿尔茨海默氏症相关痴呆症的免疫调节作用。

IF 2.9 3区医学 Q2 NEUROSCIENCES Neuroscience Pub Date : 2024-11-26 DOI:10.1016/j.neuroscience.2024.11.062

Alireza Mohammad Hosseini , Hossein Khaleghzadeh‐Ahangar , Atena Rahimi

{"title":"迷幻药对阿尔茨海默氏症相关痴呆症的免疫调节作用。","authors":"Alireza Mohammad Hosseini , Hossein Khaleghzadeh‐Ahangar , Atena Rahimi","doi":"10.1016/j.neuroscience.2024.11.062","DOIUrl":null,"url":null,"abstract":"<div><div>Dementia is an increasing disorder, and Alzheimer’s disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD. Psychedelics by 5HT<sub>2A</sub>R activation can reduce proinflammatory cytokine levels (TNF-α, IL-6) and inhibit neuroinflammation. In addition to neuroinflammation suppression, psychedelics induce neuroplasticity by increasing Brain-derived neurotrophic factor (BDNF) levels through Sigma-1R stimulation. This review discussed the effects of psychedelics on AD from both neuroinflammatory and neuroplasticity standpoints.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"564 ","pages":"Pages 271-280"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The immunomodulatory effects of psychedelics in Alzheimer’s disease-related dementia\",\"authors\":\"Alireza Mohammad Hosseini , Hossein Khaleghzadeh‐Ahangar , Atena Rahimi\",\"doi\":\"10.1016/j.neuroscience.2024.11.062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Dementia is an increasing disorder, and Alzheimer’s disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD. Psychedelics by 5HT<sub>2A</sub>R activation can reduce proinflammatory cytokine levels (TNF-α, IL-6) and inhibit neuroinflammation. In addition to neuroinflammation suppression, psychedelics induce neuroplasticity by increasing Brain-derived neurotrophic factor (BDNF) levels through Sigma-1R stimulation. This review discussed the effects of psychedelics on AD from both neuroinflammatory and neuroplasticity standpoints.</div></div>\",\"PeriodicalId\":19142,\"journal\":{\"name\":\"Neuroscience\",\"volume\":\"564 \",\"pages\":\"Pages 271-280\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306452224006511\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306452224006511","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

痴呆症是一种日益严重的疾病，阿尔茨海默病（AD）是造成 60% 痴呆症病例的原因。尽管做出了种种努力，但目前还没有阻止痴呆症发展的特效药。最近的研究报告称，迷幻药对阿兹海默病期间的神经炎症有潜在影响。迷幻药通过激活5HT2AR可以降低促炎细胞因子（TNF-α、IL-6）的水平，抑制神经炎症。除了抑制神经炎症外，迷幻药还能通过刺激 Sigma-1R 增加脑源性神经营养因子（BDNF）的水平，从而诱导神经可塑性。这篇综述从神经炎症和神经可塑性两个角度讨论了迷幻药对注意力缺失症的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The immunomodulatory effects of psychedelics in Alzheimer’s disease-related dementia

Dementia is an increasing disorder, and Alzheimer’s disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD. Psychedelics by 5HT_2AR activation can reduce proinflammatory cytokine levels (TNF-α, IL-6) and inhibit neuroinflammation. In addition to neuroinflammation suppression, psychedelics induce neuroplasticity by increasing Brain-derived neurotrophic factor (BDNF) levels through Sigma-1R stimulation. This review discussed the effects of psychedelics on AD from both neuroinflammatory and neuroplasticity standpoints.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.