病例报告:使用戈利木单抗治疗溃疡性结肠炎相关脊柱关节炎至妊娠 27 周。

IF 0.8 Q4 OBSTETRICS & GYNECOLOGY Obstetric Medicine Pub Date : 2024-11-26 DOI:10.1177/1753495X241297559
Ryuichi Okazaki, Ikkou Hirata, Hinako Ikegami, Ryou Rokutanda, Ryohkan Funakoshi
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引用次数: 0

摘要

虽然肿瘤坏死因子抑制剂被推荐用于预防溃疡性结肠炎(UC)孕妇的病情复发,但有关孕期使用戈利木单抗的研究却很少。在此,我们介绍一位患有溃疡性结肠炎和脊柱关节炎的39岁女性患者。患者希望治疗用药间隔时间长,以尽量减少对其工作生活的影响。考虑到戈利木单抗的给药间隔时间较长,我们在与患者、医生和药剂师讨论后为其开具了处方。患者在怀孕期间临床症状得到缓解,并顺利产下一名健康婴儿。患者按照疫苗接种计划接种了疫苗:在婴儿出生后的第一年里,既没有发生活疫苗引起的感染,也没有发生接种疫苗旨在预防的疾病。总体而言,本病例表明,妊娠期戈利木单抗治疗可能是可行的;但是,还需要进一步的评估,包括药物层面的分析。
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Case report: Ulcerative colitis-related spondyloarthritis treated with golimumab until 27 weeks of gestation.

Although tumor necrosis factor inhibitors are recommended for preventing flare-ups in pregnant women with ulcerative colitis (UC), studies on golimumab use during pregnancy are scant. Herein, we present a 39-year-old woman with UC and spondyloarthritis. The patient preferred treatment with a long dosing interval that minimally affects the working life of the patient. Golimumab, considering its long dosing interval, was prescribed after discussion with the patient, physician and pharmacists. Clinical remission was achieved during pregnancy, and the patient delivered a healthy baby. The vaccines were administered according to the vaccine schedule: during the first year after birth, there were neither infections caused by live vaccines nor diseases that the administered vaccines are meant to prevent. Overall, this case suggests that golimumab treatment during pregnancy may be compatible; however, further evaluations, including drug-level analysis, are needed.

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来源期刊
Obstetric Medicine
Obstetric Medicine OBSTETRICS & GYNECOLOGY-
CiteScore
1.90
自引率
0.00%
发文量
60
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