Emine Özge Karaca , Ebru Mızrak , Nevin Gürbüz , Erdem Çetinkaya , Hüseyin Karcı , Muhammed Dündar , İlknur Özdemir , Ahmet Koç , İsmail Özdemir , Waleed koko , Sadeq M. Al-Hazmy , Naceur Hamdi
{"title":"新型n -杂环碳银(I)配合物：合成、结构表征、抗菌和细胞毒性潜力研究","authors":"Emine Özge Karaca , Ebru Mızrak , Nevin Gürbüz , Erdem Çetinkaya , Hüseyin Karcı , Muhammed Dündar , İlknur Özdemir , Ahmet Koç , İsmail Özdemir , Waleed koko , Sadeq M. Al-Hazmy , Naceur Hamdi","doi":"10.1016/j.ica.2024.122458","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, a new series of 1-(2-ethylhexyl)-3-(alkyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I) complexes has been synthesized and investigated their in vitro antibacterial, antifungal and anticancer properties. All molecules were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and IR spectroscopy techniques. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: <em>Escherichia coli</em> (ATCC 25922), <em>Staphylococcus aureus</em> (ATCC 29213) and <em>Pseudomonas aeruginosa</em> (ATCC 27853), <em>Candida albicans</em> (ATCC MYA-2876) and <em>Candida glabrata</em> (ATCC 2001). Anticancer properties of samples were evaluated against <em>A549</em>, <em>HCT116</em> and <em>BEAS-2B</em> cells lines. All silver-NHC complexes showed antibacterial activity against the tested bacterial and fungal strains.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"577 ","pages":"Article 122458"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, antimicrobial and cytotoxicity potential studies\",\"authors\":\"Emine Özge Karaca , Ebru Mızrak , Nevin Gürbüz , Erdem Çetinkaya , Hüseyin Karcı , Muhammed Dündar , İlknur Özdemir , Ahmet Koç , İsmail Özdemir , Waleed koko , Sadeq M. Al-Hazmy , Naceur Hamdi\",\"doi\":\"10.1016/j.ica.2024.122458\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In this study, a new series of 1-(2-ethylhexyl)-3-(alkyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I) complexes has been synthesized and investigated their in vitro antibacterial, antifungal and anticancer properties. All molecules were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and IR spectroscopy techniques. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: <em>Escherichia coli</em> (ATCC 25922), <em>Staphylococcus aureus</em> (ATCC 29213) and <em>Pseudomonas aeruginosa</em> (ATCC 27853), <em>Candida albicans</em> (ATCC MYA-2876) and <em>Candida glabrata</em> (ATCC 2001). Anticancer properties of samples were evaluated against <em>A549</em>, <em>HCT116</em> and <em>BEAS-2B</em> cells lines. All silver-NHC complexes showed antibacterial activity against the tested bacterial and fungal strains.</div></div>\",\"PeriodicalId\":13599,\"journal\":{\"name\":\"Inorganica Chimica Acta\",\"volume\":\"577 \",\"pages\":\"Article 122458\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganica Chimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020169324005498\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020169324005498","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
In this study, a new series of 1-(2-ethylhexyl)-3-(alkyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I) complexes has been synthesized and investigated their in vitro antibacterial, antifungal and anticancer properties. All molecules were characterized by 1H NMR, 13C NMR, and IR spectroscopy techniques. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC MYA-2876) and Candida glabrata (ATCC 2001). Anticancer properties of samples were evaluated against A549, HCT116 and BEAS-2B cells lines. All silver-NHC complexes showed antibacterial activity against the tested bacterial and fungal strains.
期刊介绍：
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.
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