睡眠质量差的老年人血管周围空间水分弥漫性降低

IF 2.9 3区 医学 Q2 NEUROSCIENCES Journal of Neuroscience Research Pub Date : 2024-11-29 DOI:10.1002/jnr.70005
Junko Kikuta, Koji Kamagata, Kaito Takabayashi, Yayoi Hayakawa, Toshiaki Taoka, Yuya Saito, Wataru Uchida, Sen Guo, Seina Yoshida, Keigo Yamazaki, Akihiko Wada, Hideyoshi Kaga, Yoshifumi Tamura, Ryuzo Kawamori, Hirotaka Watada, Shigeki Aoki
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引用次数: 0

摘要

本研究纳入52名匹兹堡睡眠质量指数(PSQI)评分为5分的日本老年人和52名PSQI评分≤5分的健康对照者。采用3T磁共振成像获取弥散加权成像(DWI)和三维t1加权成像。利用预处理后的DWI计算沿血管周围空间扩散张量图像分析(DTI-ALPS)指数。使用FreeSurfer 6.0计算脉络膜丛体积(CPV)。采用一般线性模型比较睡眠质量差的老年人(PSQ)和hc的平均ALPS指数和CPV,校正协变量包括年龄、性别、受教育年限、总颅内容积、收缩压、血红蛋白A1c和白质病变体积。我们还进行了平均ALPS指数与CPV、蒙特利尔认知评估(MoCA)和PSQI评分之间的偏相关分析,并对所有上述协变量进行了调整。PSQ组的平均ALPS指数明显低于hc组。PSQ组平均ALPS指数与CPV呈负相关,与MoCA评分呈正相关。因此,患有PSQ的老年人可能在髓静脉周围的血管周围空间的排泄途径中出现功能障碍。这种损伤可能与CPV增加和认知功能障碍有关。
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Decreased Water Diffusivity Along the Perivascular Space in Older Adults With Poor Sleep Quality

This study included 52 Japanese older adults with Pittsburgh Sleep Quality Index (PSQI) scores > 5 and 52 healthy controls (HCs) with PSQI score ≤ 5. Diffusion-weighted imaging (DWI) and 3D T1-weighted imaging were acquired using 3T magnetic resonance imaging. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was calculated using preprocessed DWI. The choroid plexus volume (CPV) was calculated using FreeSurfer 6.0. The mean ALPS index and CPV were compared between the older adults with poor sleep quality (PSQ) and HCs using a general linear model, adjusted for covariates including age, sex, years of education, total intracranial volume, systolic blood pressure, hemoglobin A1c, and white matter lesion volume. We also conducted a partial correlation analysis between the mean ALPS index and CPV, Montreal Cognitive Assessment (MoCA), and PSQI scores, adjusting for all the mentioned covariates. The PSQ group had a significantly lower mean ALPS index than HCs. The mean ALPS index in the PSQ group was negatively correlated with CPV and positively correlated with the MoCA score. Therefore, older adults with PSQ may experience dysfunction in the excretory pathway of the perivascular space around the medullary veins. This impairment may be associated with an increase in CPV and cognitive dysfunction.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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