Madhura M M, Pushparaj Shetty, Naresh Yajamanam, Shwetha A Neralakatte, Preethi Hegde, Nireeksha Shetty, Mehaboob Ali, Kundubai A, Mamatha Kshatriya
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Evaluate the Role of Phosphodiesterase, Myeloperoxidase and Iron in Oral Cancer.
Objective: The present study aimed to estimate the levels of phosphodiesterase (PDE), myeloperoxidase (MPO) and iron levels in patients with oral cancer.
Method: 50 patients reporting to the Department of Oral Medicine and Radiology A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore were recruited for the study after taking informed consent. The study group consists of 50 control groups with no complications and 50 oral cancer patients. A 5 ml venous Blood sample was taken, centrifuged and serum was collected for subsequent analysis. 50 normal control samples were also collected for comparison purposes. PDE, MPO and iron levels were estimated.
Results: PDE levels were significantly elevated in the case group compared to the control. MPO and iron levels were significantly reduced in the case group compared to the control.
Conclusion: Immunological and biochemical assessment of oral precancer and cancer patients may help in earlier diagnosis and/or prognosis of these lesions. This may also serve in predicting the malignant potential of the pre-malignant lesions.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
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