4个新的石竹烯倍半萜类化合物的分离纯化。

IF 2.9 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2024-11-29 DOI:10.1002/cbdv.202402414

Yu-Ting Wang, Yuan Dong, Fang Wang, Shuai-Ming Zhu, Yang Zhang, Yu Yang, Rui Xu, Cai-Hong Dong, You-Zhi Zhang, Chang-Wei Li

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引用次数: 0

摘要

从蘑菇菌丝菌落819的发酵产物中分离出4个先前未被描述的石竹烯倍半萜类化合物（1-4）和1个已知的烯类倍半萜类化合物(5)。通过综合光谱数据分析、核磁共振计算、ORD数据及其生物合成途径，确定了1-4具有罕见三环骨架（6/5/4）或双环骨架（9/4）的结构。化合物1 ~ 5在40 μM下对小鼠小胶质细胞（BV2）、乳腺癌细胞（MCF-7）和人肺癌细胞（A549）仅表现出极弱的细胞毒性。此外，在128 μg/mL浓度下，没有化合物对金黄色葡萄球菌或大肠杆菌表现出抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Four New Caryophyllene Sesquiterpenoids Isolated From Hypholoma capnoides 819

Four previously undescribed caryophyllene sesquiterpenoids (1–4) along with one known drimane sesquiterpenoid (5) were isolated from the fermentation products of the mushroom Hypholoma capnoides 819. The structures of 1–4 with rare tricyclic skeleton (6/5/4) or bicyclic skeletons (9/4) were determined on the basis of comprehensive spectroscopic data analysis, calculated NMR, ORD data, and their biosynthetic pathways. Compounds 1–5 only showed very weak cytotoxicity toward mouse microglial cells (BV2), breast cancer cells (MCF-7), and human lung cancer cells (A549) at 40 µM. In addition, none of the compounds demonstrated antibacterial activity against Staphylococcus aureus or Escherichia coli at 128 µg/mL.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.